Structure of PDB 1yjw Chain D Binding Site BS02

Receptor Information

>1yjw Chain D (length=140) Species: 2238 (Haloarcula marismortui)

FHEMREPRIEKVVVHMGIGHANAEDILGEITGQMPVRTKAKRTVGEFDIR
EGDPIGAKVTLRDEMAEEFLQTALPLAELATSQFDDTGNFSFGLDVTVNL
VRPGYRVAKRDKASRSIPTKHRLNPADAVAFIESTYDVEV

Ligand information

>1yjw Chain 9 (length=122)

uuaggcggccacagcggugggguugccucccguacccaucccgaacacgg
aagauaagcccaccagcguuccagggaguacuggagugcgcgagccucug
ggaaauccgguucgccgccacc

...<<<<<<....<<<<<<<<......<<<<<...............>>>
..>>....>>>>>>.>><..<<.<<.....<<<<<<.<<....>>>>>>>
>....>>.>>.>.>>>>>>...

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1yjw Structures of Mlsbk Antibiotics Bound to Mutated Large Ribosomal Subunits Provide a Structural Explanation for Resistance.
• Resolution: 2.9 Å
• Binding residue (original residue number in PDB): E12 M13 R14 R17 Q47 M48 P49 V50 R51 K72 V73 T74 R76 P137 G138 R140 V141 D145 R149 P152 K154 H155
• Binding residue (residue number reindexed from 1): E3 M4 R5 R8 Q33 M34 P35 V36 R37 K58 V59 T60 R62 P103 G104 R106 V107 D111 R115 P118 K120 H121

Gene Ontology

Molecular Function

• GO:0000049 tRNA binding
• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0019843 rRNA binding

Biological Process

• GO:0006412 translation

Cellular Component

• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:1yjw, PDBe:1yjw, PDBj:1yjw
• PDBsum: 1yjw
• PubMed: 15851032
• UniProt: P14124|RL5_HALMA Large ribosomal subunit protein uL5 (Gene Name=rpl5)