Structure of PDB 1s76 Chain D Binding Site BS02

Receptor Information
>1s76 Chain D (length=829) Species: 10760 (Escherichia phage T7) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SDIELAAIPFNTLADHYGERLAREQLALEHESYEMGEARFRKMFERQLKA
GEVADNAAAKPLITTLLPKMIARINDWFEEVKAKRGKRPTAFQFLQEIKP
EAVAYITIKTTLACLTSADNTTVQAVASAIGRAIEDEARFGRIRDLEAKH
FKKNVEEQLNKRVGHVYKKAFMQVVEADMLSKGAWSSWHKEDSIHVGVRC
IEMLIESTGMVSLHRQSETIELAPEYAEAIATRAGALAGISPMFQPCVVP
PKPWTGITGGGYWANGRRPLALVRTHSKKALMRYEDVYMPEVYKAINIAQ
NTAWKINKKVLAVANVITKWKHCPVEDIPAIEREELPMTAWKRAAAAVYR
KDKARKSRRISLEFMLEQANKFANHKAIWFPYNMDWRGRVYAVSMFNPQG
NDMTKGLLTLAKGKPIGKEGYYWLKIHGANCAGVDKVPFPERIKFIEENH
ENIMACAKSPLENTWWAEQDSPFCFLAFCFEYAGVQHHGLSYNCSLPLAF
DGSCSGIQHFSAMLRDEVGGRAVNLLPSETVQDIYGIVAKKVNEILQADA
INGTDNEGTKALAGQWLAYGVTRSVTKRSVMTLAYGSKEFGFRQQVLEDT
IQPAIDSGKGLMFTQPNQAAGYMAKLIWESVSVTVVAAVEAMNWLKSAAK
LLAAEVKDKKTGEILRKRCAVHWVTPDGFPVWQEYKKPIQTRLNLMFLGQ
FRLQPTINTNKDSEIDAHKQESGIAPNFVHSQDGSHLRKTVVWAHEKYGI
ESFALIHDSFGTIPADAANLFKAVRETMVDTYESCDVLADFYDQFADQLH
ESQLDKMPALPAKGNLNLRDILESDFAFA
Ligand information
Receptor-Ligand Complex Structure
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PDB1s76 The structural mechanism of translocation and helicase activity in T7 RNA polymerase.
Resolution2.88 Å
Binding residue
(original residue number in PDB)		E168 R173 Y178 K378 R379 A382 Y385 R647 P670 K704
Binding residue
(residue number reindexed from 1)		E157 R162 Y167 K342 R343 A346 Y349 R593 P616 K650
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0034062 5'-3' RNA polymerase activity
Biological Process
GO:0006351 DNA-templated transcription
GO:0019083 viral transcription
GO:0039695 DNA-templated viral transcription
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1s76, PDBe:1s76, PDBj:1s76
PDBsum1s76
PubMed15016374
UniProtP00573|RPOL_BPT7 T7 RNA polymerase (Gene Name=1)

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