Structure of PDB 1lw5 Chain D Binding Site BS02

Receptor Information

>1lw5 Chain D (length=344) Species: 2336 (Thermotoga maritima) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

MMIDLRSDTVTKPTEEMRKAMAQAEVGDDVYGEDPTINELERLAAETFGK
EAALFVPSGTMGNQVSIMAHTQRGDEVILEADSHIFWYEVGAMAVLSGVM
PHPVPGKNGAMDPDDVRKAIRPRNIHFPRTSLIAIENTHNRSGGRVVPLE
NIKEICTIAKEHGINVHIDGARIFNASIASGVPVKEYAGYADSVMFCLSK
GLCAPVGSVVVGDRDFIERARKARKMLGGGMRQAGVLAAAGIIALTKMVD
RLKEDHENARFLALKLKEIGYSVNPEDVKTNMVILRTDNLKVNAHGFIEA
LRNSGVLANAVSDTEIRLVTHKDVSRNDIEEALNIFEKLFRKFS

Ligand information

Ligand ID

InChI

InChI=1S/Ca/q+2

InChIKey

BHPQYMZQTOCNFJ-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Ca++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Ca+2]

Formula

Name

CALCIUM ION

PDB chain

1lw5 Chain D Residue 1009 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	1lw5 X-ray Structures of Threonine Aldolase Complexes: Structural Basis of Substrate Recognition
Resolution	2.05 Å
Binding residue (original residue number in PDB)	N326 E329
Binding residue (residue number reindexed from 1)	N327 E330
Annotation score	1

Enzymatic activity

Enzyme Commision number

4.1.2.5: L-threonine aldolase.

Gene Ontology

	Molecular Function
GO:0008732	L-allo-threonine aldolase activity
GO:0016829	lyase activity
GO:0046872	metal ion binding

	Biological Process
GO:0006520	amino acid metabolic process
GO:0006545	glycine biosynthetic process
GO:0006567	threonine catabolic process

	Cellular Component
GO:0005829	cytosol

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Molecular Function

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Cellular Component

External links

PDB	RCSB:1lw5, PDBe:1lw5, PDBj:1lw5
PDBsum	1lw5
PubMed	12269813
UniProt	Q9X266

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