Structure of PDB 1j2g Chain D Binding Site BS02

Receptor Information
>1j2g Chain D (length=306) Species: 36824 (Bacillus sp. TB-90) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RVMYYGKGDVFAYRTYLKPLTGVRTIPESPFSGRDHILFGVNVKISVGGT
KLLTSFTKGDNSLVVATDSMKNFIQKHLASYTGTTIEGFLEYVATSFLKK
YSHIEKISLIGEEIPFETTFAVKNGNRAASELVFKKSRNEYATAYLNMVR
NEDNTLNITEQQSGLAGLQLIKVSGNSFVGFIRDEYTTLPEDSNRPLFVY
LNIKWKYKNTEDSFGTNPENYVAAEQIRDIATSVFHETETLSIQHLIYLI
GRRILERFPQLQEVYFESQNHTWDKIVEEIPESEGKVYTEPRPPYGFQCF
TVTQED
Ligand information
Ligand IDAZA
InChIInChI=1S/C4H3N5O2/c10-3-1-2(8-9-7-1)5-4(11)6-3/h(H3,5,6,7,8,9,10,11)
InChIKeyKVGVQTOQSNJTJI-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341O=C1NC(=O)c2nn[nH]c2N1
OpenEye OEToolkits 1.5.0c12c([nH]nn1)NC(=O)NC2=O
ACDLabs 10.04O=C2Nc1nnnc1C(=O)N2
FormulaC4 H3 N5 O2
Name8-AZAXANTHINE
ChEMBLCHEMBL219341
DrugBankDB01875
ZINCZINC000018123155
PDB chain1j2g Chain D Residue 3320 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1j2g Crystal structure of urate oxidase from Bacillus SP.
Resolution2.2 Å
Binding residue
(original residue number in PDB)		F184 R201 S248 I249 Q250
Binding residue
(residue number reindexed from 1)		F178 R195 S242 I243 Q244
Annotation score2
Enzymatic activity
Catalytic site (original residue number in PDB) K13 T73 R201 Q250 T278
Catalytic site (residue number reindexed from 1) K7 T67 R195 Q244 T272
Enzyme Commision number 1.7.3.3: factor independent urate hydroxylase.
4.1.1.97: 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase.
Gene Ontology
Molecular Function
GO:0004846 urate oxidase activity
Biological Process
GO:0006144 purine nucleobase metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:1j2g, PDBe:1j2g, PDBj:1j2g
PDBsum1j2g
PubMed
UniProtQ45697|PUCL_BACSB Uric acid degradation bifunctional protein (Gene Name=uao)

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