Structure of PDB 1i6v Chain D Binding Site BS02

Receptor Information
>1i6v Chain D (length=1174) Species: 271 (Thermus aquaticus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KEVRKVRIALASPEKIRSWSYGEVEKPETEAKVCERCAVEVTRSIVRRYR
MAHIELATPAAHIWFVKDVPSKIATLLDLSATELEQVLYFNKYIVLDPKA
AVLDAVPVEKRQLLTDAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAIDARMGAEAIQELLKELDLEKLERELLEEMKHPSRARRAKARKRLEVV
RAFLDSGNRPEWMILEAVPVLPPDATSDLNDLYRRLINRNNRLKKLLAQG
APEIIIRNEKRMLQEAVDAVIDNGRRGSPVTNPGSERPLRSLTDILSGKQ
GRFRQNLLGKRVDYSGRSVIVVGPQLKLHQCGLPKRMALELFKPFLLKKM
EEKAFAPNVKAARRMLERQRDIKDEVWDALEEVIHGKVVLLNRAPTLHRL
GIQAFQPVLVEGQSIQLHPLVCEAFNADFDGDQMAVHVPLSSFAQAEARI
QMLSAHNLLSPASGEPLAKPSRDIILGLYYITQVRKEKKGAGMAFATPEE
ALAAYERGEVALNAPIVVAGRETSVGRLKFVFANPDEALLAVAHGLLDLQ
DTVTTRYLGRRLETSPGRILFARIVGEAVGDEKVAQELIQMDVPQEKNSL
KDLVYQAFLRLGMEKTARLLDALKYYGFTLSTTSGITIGIDDAVIPEEKQ
RYLEEADRKLRQIEQAYEMGFLTDRERYDQVIQLWTETTEKVTQAVFNNF
EENYPFNPLYVMAQSGARGNPQQIRQLCGMRGLMQKPSGETFEVPVRSSF
REGLTVLEYFISSHGARKGGADTALRTADSGYLTRKLVDVAHEIVVREAD
CGTTNYISVPLFQMDEVTRTLRLRKRSDIESGLYGRVLAREVEALGRRLE
EGRYLSLEDVHFLIKAAEAGEVREVPVRSPLTCQTRYGVCQKCYGYDLSM
ARPVSIGEAVGVVAAESIGEPGTQLTMRTGTDITQGLPRVIELFEARRPK
AKAVISEIDGVVRIEEGEDRLSVFVESEGFSKEYKLPKDARLLVKDGDYV
EAGQPLTRGAIDPHQLLEAKGPEAVERYLVDEIQKVYRAQGVKLHDKHIE
IVVRQMLKYVEVTDPGDSRLLEGQVLEKWDVEALNERLIAVPVAWKPLLM
GVTKSALSTKSWLSAASFQNTTHVLTEAAIAGKKDELIGLKENVILGRLI
PAGTGSDFVRFTQVVDQRTLKAIE
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain1i6v Chain D Residue 1601 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB1i6v Structural mechanism for rifampicin inhibition of bacterial rna polymerase.
Resolution3.3 Å
Binding residue
(original residue number in PDB)		C1201 C1204
Binding residue
(residue number reindexed from 1)		C890 C893
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
Biological Process
GO:0006351 DNA-templated transcription

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:1i6v, PDBe:1i6v, PDBj:1i6v
PDBsum1i6v
PubMed11290327
UniProtQ9KWU6|RPOC_THEAQ DNA-directed RNA polymerase subunit beta' (Gene Name=rpoC)

[Back to BioLiP]