Structure of PDB 1gxc Chain D Binding Site BS02
Receptor Information
>1gxc Chain D (length=116) Species:
9606
(Homo sapiens) [
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PWARLWALQDGFANLECVNDNYWFGRDKSCEYCFDEPLLKRTDKYRTYSK
KHFRIFREVGPKNSYIAYIEDHSGNGTFVNTELVGKGKRRPLNNNSEIAL
SLSRNKVFVFFDLTVD
Ligand information
>1gxc Chain E (length=8) Species:
32630
(synthetic construct) [
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HFDTYLIR
Receptor-Ligand Complex Structure
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PDB
1gxc
Structural and Functional Versatility of the Fha Domain in DNA-Damage Signaling by the Tumor Suppressor Kinase Chk2
Resolution
2.7 Å
Binding residue
(original residue number in PDB)
R117 D118 K119 Y136 R137 T138 Y139 S140 K141 N166 S192
Binding residue
(residue number reindexed from 1)
R26 D27 K28 Y45 R46 T47 Y48 S49 K50 N75 S101
Enzymatic activity
Enzyme Commision number
2.7.11.1
: non-specific serine/threonine protein kinase.
External links
PDB
RCSB:1gxc
,
PDBe:1gxc
,
PDBj:1gxc
PDBsum
1gxc
PubMed
12049740
UniProt
O96017
|CHK2_HUMAN Serine/threonine-protein kinase Chk2 (Gene Name=CHEK2)
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