Structure of PDB 1gxb Chain D Binding Site BS02

Receptor Information

>1gxb Chain D (length=345) Species: 2287 (Saccharolobus solfataricus)

MNINEILKKLINKSDLEINEAEELAKAIIRGEVPEILVSAILVALRMKGE
SKNEIVGFARAMRELAIKIDVPNAIDTAGTGGDGLGTVNVSTASAILLSL
VNPVAKHGNRAVSGKSGSADVLEALGYNIIVPPERAKELVNKTNFVFLFA
QYYHPAMKNVANVRKTLGIRTIFNILGPLTNPANAKYQLMGVFSKDHLDL
LSKSAYELDFNKIILVYGEPGIDEVSPIGNTFMKIVSKRGIEEVKLNVTD
FGISPIPIEKLIVNSAEDSAIKIVRAFLGKDEHVAEFIKINTAVALFALD
RVGDFREGYEYADHLIEKSLDKLNEIISMNGDVTKLKTIVVKSSG

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 1gxb Chain D Residue 1350

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1gxb Structural Analysis of Two Enzymes Catalysing Reverse Metabolic Reactions Implies Common Ancestry
• Resolution: 2.65 Å
• Binding residue (original residue number in PDB): G79 S91 D223 E224
• Binding residue (residue number reindexed from 1): G79 S91 D223 E224
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 2.4.2.18: anthranilate phosphoribosyltransferase.

Gene Ontology

Molecular Function

• GO:0000287 magnesium ion binding
• GO:0004048 anthranilate phosphoribosyltransferase activity
• GO:0016757 glycosyltransferase activity
• GO:0016763 pentosyltransferase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0000162 tryptophan biosynthetic process

Cellular Component

• GO:0005829 cytosol

External links

• PDB: RCSB:1gxb, PDBe:1gxb, PDBj:1gxb
• PDBsum: 1gxb
• PubMed: 12093726
• UniProt: P50384|TRPD_SACS2 Anthranilate phosphoribosyltransferase (Gene Name=trpD)