Structure of PDB 1fz9 Chain D Binding Site BS02

Receptor Information

>1fz9 Chain D (length=388) Species: 414 (Methylococcus capsulatus)

SMLGERRRGLTDPEMAAVILKALPEAPLDGNNKMGYFVTPRWKRLTEYEA
LTVYAQPNADWIAGGLDWGDWTQKFHGGRPSWGNETTELRTVDWFKHRDP
LRRWHAPYVKDKAEEWRYTDRFLQGYSADGQIRAMNPTWRDEFINRYWGA
FLFNEYGLFNAHSQGAREALSDVTRVSLAFWGFDKIDIAQMIQLERGFLA
KIVPGFDESTAVPKAEWTNGEVYKSARLAVEGLWQEVFDWNESAFSVHAV
YDALFGQFVRREFFQRLAPRFGDNLTPFFINQAQTYFQIAKQGVQDLYYN
CLGDDPEFSDYNRTVMRNWTGKWLEPTIAALRDFMGLFAKLPAGTTDKEE
ITASLYRVVDDWIEDYASRIDFKADRDQIVKAVLAGLK

Ligand information

• Ligand ID: ETI
• InChI: InChI=1S/C2H5I/c1-2-3/h2H2,1H3
• InChIKey: HVTICUPFWKNHNG-UHFFFAOYSA-N
• SMILES:
  ACDLabs 11.02: ICC
  CACTVS 3.352
  OpenEye OEToolkits 1.7.0: CCI
• Formula: C2 H5 I
• Name: IODOETHANE
• PDB chain: 1fz9 Chain D Residue 9001

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1fz9 Xenon and halogenated alkanes track putative substrate binding cavities in the soluble methane monooxygenase hydroxylase.
• Resolution: 2.3 Å
• Binding residue (original residue number in PDB): E116 Q283 T286 Y287
• Binding residue (residue number reindexed from 1): E115 Q282 T285 Y286
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 1.14.13.25: methane monooxygenase (soluble).

Gene Ontology

Molecular Function

• GO:0004497 monooxygenase activity
• GO:0005515 protein binding
• GO:0015049 methane monooxygenase [NAD(P)H] activity
• GO:0016491 oxidoreductase activity
• GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

Biological Process

• GO:0006730 one-carbon metabolic process

External links

• PDB: RCSB:1fz9, PDBe:1fz9, PDBj:1fz9
• PDBsum: 1fz9
• PubMed: 11297413
• UniProt: P18798|MEMB_METCA Methane monooxygenase component A beta chain (Gene Name=mmoY)