Structure of PDB 1d00 Chain D Binding Site BS02
Receptor Information
>1d00 Chain D (length=168) Species:
9606
(Homo sapiens) [
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AMADLEQKVLEMEASTYDGVFIWKISDFARKRQEAVAGRIPAIFSPAFYT
SRYGYKMCLRIYLNGDGTGRGTHLSLFFVVMKGPNDALLRWPFNQKVTLM
LLDQNNREHVIDAFRPDVTSSSFQRPVNDMNIASGCPLFCPVSKMEAKNS
YVRDDAIFIKAIVDLTGL
Ligand information
>1d00 Chain P (length=5) Species:
9606
(Homo sapiens) [
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PVQET
Receptor-Ligand Complex Structure
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PDB
1d00
The structural basis for the recognition of diverse receptor sequences by TRAF2.
Resolution
2.0 Å
Binding residue
(original residue number in PDB)
K429 F447 R448
Binding residue
(residue number reindexed from 1)
K96 F114 R115
Enzymatic activity
Enzyme Commision number
2.3.2.27
: RING-type E3 ubiquitin transferase.
Gene Ontology
Molecular Function
GO:0004842
ubiquitin-protein transferase activity
GO:0005164
tumor necrosis factor receptor binding
Biological Process
GO:0007250
activation of NF-kappaB-inducing kinase activity
GO:0033209
tumor necrosis factor-mediated signaling pathway
GO:0042981
regulation of apoptotic process
GO:0046328
regulation of JNK cascade
GO:0051865
protein autoubiquitination
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Molecular Function
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Biological Process
External links
PDB
RCSB:1d00
,
PDBe:1d00
,
PDBj:1d00
PDBsum
1d00
PubMed
10518213
UniProt
Q12933
|TRAF2_HUMAN TNF receptor-associated factor 2 (Gene Name=TRAF2)
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