Structure of PDB 6hiy Chain Cv Binding Site BS02

Receptor Information
>6hiy Chain Cv (length=1059) Species: 5702 (Trypanosoma brucei brucei) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LKTLDVREYRPLAMPIEFRFYQRYANHPNRQSGIQFLTHYNTHQRFRVNK
DYIDYMHWGKEQGQARLPHRHQRVAFDFNDQLHPTRIGYAWFASQDPTFG
HHPDLSSSFDPNYRVFSHPEHWNKMFTKRRPGEGDIDLSVLPSRSLLGPL
MAHSDTKGIPYFKVDNRGHSNGRVPGVNAPFFGEFDQKMMQAMSRPLNAN
RTITGNDGRFSKTIMINEPQCNQALSAKTASELSKEIDKATNAVYSKLSV
LEAAQSGLTDYFCGGLNFEIVGFELHMAAMLRERAAAILERSGACAMLLE
KADEREVNKLLRDASRYEDRVDDALRQHASLIWRVYTAPRPLMTLTNGKC
RGTGCGLSLFAKYCALKDSSEFIFDGPNVGITPYGGMTRLLARPETSLKY
PGLAEFVVLTGASLFAGDALRLGWTDLFTTIPDMTYHIKEWFDTTEHMHN
DAVAWQLGHLLETCFKMKESHSSAMERAAITPTRARWVEDAFADQPSVND
IMRTLTEIEQLPFQSTHNTSDESHITPYTLGSVAAGVQRLGEHRLRYTLS
PWDITPPEDSVVLKHTSEMFRAYVLERRGATDVVTHRDAERAAAWSQQRQ
REYDAYCSLKEAPHPRHVYARLEGCEGKIVSFEFVFEISCTTTISRLKSR
ILDALGMPRDRNIDLGWYLPTLDTCPIHSDEELMQVLHTDPGIEDPKEKL
RYPPIYFIVKRCTLYFSEWAYAVKHQLLLQSPFALRAAFGLLQEVRGDGA
AENVMPLAETLGTEFKYFTRLMRRPDFYRVGVHTDKSVEKWEEIKEERRH
NIHHTHRPTRPLPDFEEVFERDVEIDGHRFVLRPRWNPRTLQDVDDSDIL
RLRAPLTYDMDSTAALHVPTHCGKASRLAGMLQDAGGVQVLDGLGEVDDK
GEPKVPPLQSNASVPTNVSFYEMARHPWEDRASSWRRDGFTEGSLEYFES
QYRSAERAVYDEEGRGVRNYWPSRDAVEGIAQEEENDAQLLQERLFNTLE
TAGTSVEPWARNLRLNATTGKFGYKTEIATQEEKIYDDEYYRWFIQPGRH
PNPSGLTLN
Ligand information
>6hiy Chain UR (length=8) Species: 5702 (Trypanosoma brucei brucei) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
PPPPPPPP
Receptor-Ligand Complex Structure
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PDB6hiy Evolutionary shift toward protein-based architecture in trypanosomal mitochondrial ribosomes.
Resolution3.27 Å
Binding residue
(original residue number in PDB)		D554 A557 Q559 E571 H581
Binding residue
(residue number reindexed from 1)		D490 A493 Q495 E507 H517
Enzymatic activity
Enzyme Commision number 3.1.2.4: 3-hydroxyisobutyryl-CoA hydrolase.
Gene Ontology
Molecular Function
GO:0003860 3-hydroxyisobutyryl-CoA hydrolase activity
GO:0004300 enoyl-CoA hydratase activity
GO:0016787 hydrolase activity
Biological Process
GO:0006635 fatty acid beta-oxidation
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005763 mitochondrial small ribosomal subunit

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6hiy, PDBe:6hiy, PDBj:6hiy
PDBsum6hiy
PubMed30213880
UniProtQ383R4

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