Structure of PDB 8pv5 Chain Cf Binding Site BS02

Receptor Information

>8pv5 Chain Cf (length=285) Species: 759272 (Thermochaetoides thermophila DSM 1495)

PRNARSKRALEKRAPKIVENPKTCLFLRGTTCSQITQDAMNDLYAMRQVH
AKRFHKKNAIHPFEDATSLCFFSEKNDCSLMVFGSSNKKRPHTLTFVRMF
DYKVLDMLEFYLDPDTYRSISQFKTSKIPIGMRPMMVFAGTAFESPVPNA
FTMAKSMLIDFFRGEPSDKIDVEGLRFVVVVTADEPQKPILRLRVYGIRT
KRSGTRLPRVEVEEHGPRMDFRLGRMREPDPAMLKEAMKKAKTPQEERTK
KNISMDLLGDKIGRIHMGKTDLSKLQTRKMKGLKR

Ligand information

>8pv5 Chain C4 (length=119)

acguacgaccauacccaguggaaagcacggcaucccguccgcucugcccu
aguuaagccacugagggcccgguuaguaguugggucggugacgaccagcg
aaucccggguguuguacgu

<<<<<<<<<....<<<<<<<<.....<<<<<<............>>>>..
.>>....>>>>>>.>><<<<<<......<<<<.<<<<....>>>>>>>>.
....>>>>>>>>>>>>>>>

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8pv5 Structural insights into coordinating 5S RNP rotation with ITS2 pre-RNA processing during ribosome formation.
• Resolution: 2.86 Å
• Binding residue (original residue number in PDB): T36 Q43 R59 H67 E70 N93 K94 K95 R96 K130 R259
• Binding residue (residue number reindexed from 1): T30 Q37 R53 H61 E64 N87 K88 K89 R90 K124 R225

Gene Ontology

Molecular Function

• GO:0019843 rRNA binding

Biological Process

• GO:0000027 ribosomal large subunit assembly
• GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
• GO:0000470 maturation of LSU-rRNA
• GO:0006364 rRNA processing

Cellular Component

• GO:0005634 nucleus
• GO:0005730 nucleolus

External links

• PDB: RCSB:8pv5, PDBe:8pv5, PDBj:8pv5
• PDBsum: 8pv5
• PubMed: 37921038
• UniProt: G0SF80