Structure of PDB 4v7e Chain Cc Binding Site BS02

Receptor Information

>4v7e Chain Cc (length=112) Species: 4565 (Triticum aestivum)

MAPTKKAKKSGENINNKLQLVMKSGKYTLGYKTVLKTLRSSLGKLIILAN
NCPPLRKSEIETYAMLAKISVHHFHGNNVDLGTACGKYYRVCCLSILDPG
DSDIISTTTTTQ

Ligand information

>4v7e Chain Aa (length=3391)

gcgcgaccccaggucaggcgggacuaccgcugaguuuaagcauauaaaua
agcggaggagaagaaacuuacaaggauuccccuaguaacggcgagcgaac
cgggagcagcccagcuugagaaucgggcggcugugccguccgaauuguag
ucuggagaggcguccucagcgacggaccgggcccaaguccccuggaaagg
ggcgccugggagggugagagccccguccggcccggacccugucgccccac
gaggcgccgucaacgagucggguuguuugggaaugcagcccaaaucgggc
gguagacuccguccaaggcuaaauacaggcgagagaccgauagcgaacaa
guaccgcgagggaaagaugaaaaggacuuugaaaagagagucaaagagug
cuugaaauugccgggagggaagcggaugggggccggcgaugcgccccggc
cguaugcggaacggcucuugcugguccgccgcucggcucggggcguggac
uguugucggccgcgccggcggccaaagcccgggggcuccgcgcccccggc
agccgucgucggcacggccgguacccgcgcgccgaaaggcgugccccucg
gggcacugcgcugcaacgcccugcgggcuccccauccgacccgucuugaa
acacggaccaaggagucugacaugcgugcgagucgacggguucugaaacc
ugggaugcgcaaggaagcugacgagcgggaggcccucacgggccgcaccg
cuggccgacccugaucuucugugaaggguucgaguuggagcacgccuguc
gggacccgaaagauggugaacuaugccugagcggggcgaagccagaggaa
acucugguggaggcucgaagcgauacugacgugcaaaucguucgucugac
uuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguucccu
ccgaaguuucccucaggauagcuggagcccauuacgaguucuaucaggua
aagccaaugauuagaggcauuggggacgcaacguccucgaccuauucuca
aacuuuaaauagguaggauggcgcggcugcuucggugagccgugccaugg
aaucgggugcuccaagugggccauuuuugguaagcagaacuggcgaugcg
ggaugaaccggaagccggguuacggugcccaacugcgcgcuaaccuagaa
cccacaaaggguguuggucgauuaagacagcaggacgguggucauggaag
ucgaaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagc
cccgaaaauggauggcgcugaagcgcgcgacccacacccggccaucuggg
cgagugccaugccccgaugaguaggagggcgcggcggccgaugcaaaacc
cggggcgcgagcccgggcggagcggccgucggugcagaucuuggugguag
uagcaaauauucaaaugagaacuuugaaggccgaagaggagaaagguucc
augugaacggcacuugcacauggguaagccgauccuaagggaagggguaa
ccccggcagauagcgcgaucacgcgcauccccgaaagggaaucggguuaa
gauuucccgagccgggauguggcgguugacggcgacguuaggaaguccgg
agacgccggcgggggccucgggaagaguuaucuuuucugcuuaacggccu
gccaacccuggaaacgguucagccggagguaggguccaguggccggaaga
gcacacgucgcgcgguguccggugcgcccccggcggcccaugaaaauccg
gaggaccgaguaccguucacgcccggucguacucauaaccgcaucagguc
uccaaggugaacagccucuggccaauggaacaauguaggcaagggaaguc
ggcaaaacggauccguaacuucgggaaaaggauuggcucugaggacuggg
cucgggggucccggccccgaacccgucggcugucggcggauugcucgagc
ugcucacgcggcgagagcgggucgccgcgugccggccgggggacggaccg
ggaaucgccccuucgggggcuuuccccgagcaugaaacagucgacucaga
acugguacggacaaggggaauccgacuguuuaauuaaaacaaagcauugc
gaugguccucgcggaugcugacgcaaugugugauuucugcccagugcucu
gaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggagua
acuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacg
cgcaugaaugaauggauuaacgagauucccacugucccugucuacuaucc
agcgaaaccacagccaagggaacgggcuuggcggaaucagcggggaaaga
agacccuguugagcuugacucuaguccgacuuugugaaaugacuugagag
guguaggauaagugggagcccucacgggcgcaagugaaauaccacuacuu
uuaacguuauuuuacuuauuccgugggucggaagcggggcaugccccucc
uuuuggcuccaaggcccggucuuaccgggccgauccgggcggaagacauu
gucagguggggaguuuggcuggggcggccaaucuguuaaaagauaacgca
gguguccuaagaugagcucaacgagaacagaaaucucguguggaacaaaa
ggguaaaagcucguuugauucugauuuccaguacgaauacgaaccgugaa
agcguggccuaucgauccuuuagacuucggaguuugaagcuagagguguc
agaaaaguuaccacagggauuacuggcuuguggcagccaagcguucauag
cgacguugcuuuuugauccuucgaugucggcucuuccuaucauugcgaag
cagaauucaccaaguguuggauuguucacccaccaauagggaacgugagc
uggguuuagaccgucgugagacagguuaguuuuacccuacugaugacagu
gucgcgauaguaauucaaccuaguacgagaggaaccguugauucacacaa
uuggucaucgcgcuugguugaaaagccaguggcgcgaagcuaccgugugc
cggauuaugacugaacgccucuaagucagaauccaagcuagcaugcgacg
ccugcgcccgccgcccgccccgacccacguuaggggcgcuugcgccccca
agggcccgugccauuggcuaagccgguccggccgaagugccgcggucggc
cgccucgaagcucccuucccaacgggcggugggcugaauccuuugcagac
gacuuaaauacgcgacggggcauuguaaguggcagaguggccuugcugcc
acgauccacugagauccaguccccgcgucgcacggauucgu

..........................<<<<<.....<......>......
>>>>>...........<<....>>..<<<<<.......<.....>.....
.>>>>>..<<<...........<<<<<<<<<...>>>>>>>>>.......
......<<<<<<.<<<<.<<<<<<<.<<<<<<<.....<<<<......>>
>>.((......<<<.....))>>>....>>>>>>>...>>>>>>>.....
>>>>>>>>.>>........<<<<<<<........>>>>>>>.....<<<<
<..((((((>>>>>..>>>...............................
...<<....>>...............<<<<....>>>>............
........................<<<<<<<<<<.<<...<<<<<<<<<<
<<..<<<<<<.<<<<....>>>>.>>>>.>>..>>>>.>>>>>>>>....
<<<<<<<<<<<<.<<<<<<<<.......<<<<<<<<.....>>>>>>>>.
.....>>>>>>>>.>>>>>>>.....<<<<<<<....>>><<<<<<....
>>>>>>.>>>>..>>>>>....>>.>>>.>>>>>>>....<<<<......
..>>>><<<<<<.....<<<<<.<<<<<<..<<<...<<.<.....>.>>
...>>>...<......>......<<<<<..<<<<<....>>>>>...>>>
>><<<<<<<<<....<....>....>>>.>>>.>>>...>>>>>>.>>>>
>...<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<...
.>>>>>>>.....>>>...<<<<.<<.<<........>>>>>>>>....>
>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<
<<....<.<<<....>>>.><<<<<<<<.<....<<<.<<<<<<<.....
<<<....<<<....<<<....<<<<<<.....>>>>>>..>>>....>>>
..>>.>.....>>>>>...<<<<<<<<<.........>>>>>>>>>....
>>>>>.>.>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<
<......>>>...<<<<<<<...<<<(((.....<<<<<<......<<..
........<<<.<<<<<<.<<<.......<<<<<.<<.....<.......
..>.....>>.........<<......>>...>>>>>...>>>.>>>>>>
>>>..........))).>>...>>>>>>.>>>...>>>>>>><<<<.<<<
<.........>>>>.>>>>....>>>>>><<<<<<<<<<<........<<
<.<<<<....>>>>>>>.....>>>>>>>>>.>>.....>>>>>><<...
..<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<
<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<...<<<...
.>>>........<<<<<....>>>>>...>>>....>>...<<<<<....
....>>>.>>))<<<<.<<<<..<....<<<....>>>.......<<<<<
<...<<<<.<<<<<<<.<<<<<.<<<<...[[..>>>>.><...<<<<<.
....<<<<<<.....<<.....>>.....>>>>>>.....>>>>>....>
<<<<..........>>>>>>>>...>>>>>>>.>>>>.........>>>>
>>..........>....>>>>>>>>>>>>..>>.....<<......>>>>
>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<......
.........<<<<<....<....>.....>>>>><<.<<<<<<<<<<<.<
<<<<<<<.<<<<<<..<<<..<<<<<<<<<<<.<<<<<<.<<<<<<..<<
<<<....>>>>>..>>>>>>.>>>>>>>>.>>>>>>..>>>..>>>.>>>
>>>...<<<<......>>>>...>>>>>>>>......>>>>>..>>>>>>
.>>............<<<<<<<<<..<<<.........>>>..<<<..<<
....<<<<....>>>>......>>....>>>...<<<.<<<..<<<<<<.
<...<<.....<<<<....>>>>.....>>.>>>>>..>>>>><<<<<<.
......>>>>>>........<...........<<<<<.......>>>>>.
....>....>>>........>>.>>>>>>>.....>>.>>>>>>>..>>>
>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<..
....<<<<.<<<<<<..<<<<<.<<<.<<<...<<<<<<<<<<<<<<<<<
...........<<<<..<<<<....>>>>............>>>>..>>>
>>>>.>>>>>>>>>>...<<<<<.....<<<<...<<<..........>>
>................<<<<<....>>>>>..>>>>..>>>>>......
>>>.>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>
>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(
((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<...
.>>>.>>)))......<<<<<<<.<<<<.))))))>>>>>>>>>>>....
.....>>>>..>>>>>>.......<<.<.<.<<<<<<...<<.......>
>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<<<.<.<<<.
.....>>>.>...>>>.<<<.<.....>.>>>.....>>>>>..>...>>
>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>....<<
<<<<<..<<<<.<.<<<<<.................>>>>>.><<<<<..
.<<<<....<<<<<<<<<.]]...>>>>..>>>>>...>>>>..>>>>>.
.<<<...<<<<<...........>>>>>...>>>..>>>>....>>>>>>
>....<<<<<<<<<<<<......<<<......<<<<..<....>.>>>>.
.>>>...........<<<...<<<<<<.<<<<......>>>>.>.>>>>>
.>>>..................>>>>>>>>>>>>.<<<<<.<........
.....>.........<<<<<.<<<....<<<<....<<<<<......>>>
>>...>>>>...>>>....>>>>.>.........>>>>>..

Receptor-Ligand Complex Structure

Structure summary

• PDB: 4v7e Structures of the Sec61 complex engaged in nascent peptide translocation or membrane insertion.
• Resolution: 5.5 Å
• Binding residue (original residue number in PDB): L29 G30 Y31 K32 P54 L55 S58 Y89 R90
• Binding residue (residue number reindexed from 1): L29 G30 Y31 K32 P54 L55 S58 Y89 R90

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome

Cellular Component

• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:4v7e, PDBe:4v7e, PDBj:4v7e
• PDBsum: 4v7e
• PubMed: 24499919
• UniProt: Q5I7K9|RL30_WHEAT Large ribosomal subunit protein eL30