Structure of PDB 9cai Chain CS Binding Site BS02

Receptor Information

>9cai Chain CS (length=179) Species: 6239 (Caenorhabditis elegans)

PTKALGETLNEYVVVGRKIPTEKEPVTPIWKMQIFATNHVIAKSRFWYFV
SMLRRVKKANGEILSIKQVFEKNPGTVKNYGVWLKYDSRTGHHNMYREYR
DTTVAGAVTQCYRDMGARHRAQADRIHILKVQTVKAEDTKRAGIKMFHDA
KIRFPLPHRVTKRKNLSVFTTARQNTHFA

Ligand information

>9cai Chain A5 (length=3022)

cucaaccugaacucagucgugauuacccgcugaacuuaagcauaucauuu
agcggaggaaaagaaacuaaaaaggauucccuuaguaacggcgagugaaa
cgggaagagcccagcgccgaaucgaucagucuuuggcugcuucgaaaugu
ggcguauagguguaaguuuccagcagugucguauguccgaaguccuuacg
auugaggccauaaaccagagagggugcgagccccguucuggauagcggca
cuguugguucgcuugcuccuuggagucggguugcuugaaagugcagccua
aagugggugauaaacuucaucuaaggcuaaauaucgacucgauugcgaua
gcgaacaaguaccgugagggaaaguugcaaaggacuuugaagagagaguu
caagagaacgugaaaucgcuggaguggaaccggagacaguugauuacgcc
gacggcguuggcugcucguucuagcccgacaguguugcgucuugcuggcg
guaguggguucguggcggcuagcguacgucggugugaaagucgacgacgu
uuccgacccgucuugaaacacggauugcggagugcuugucuacugcgagu
caaaggguguuaaaaccuugcggcgaaaugaaaguaaaggucagucucga
auuggccgacgugggaucugugugugcagcgcaccacggcccugugcgug
ucacuugugacugugcagagguugagcaguuggcaaacgacccgaaagau
ggugaacuaugccugagcaggaugaagccagaggaaacucugguggaagu
ccguaucgguucugacgugcaaaucgaucgauagacuuggguauaggggc
gaaagacuaaucgaaccaucuaguagcugguuccuuccgaaguuucccuc
aggauagcuggaucucaggcaguuauauucgguaaagcuaaugauuagag
gaaccuauucucaaacuuucaauggauaugaaguugcaguuucuuuagug
aacugucaacgugaaugcgagguccaagugggccauuuuugguaagcaga
acuggcgcugugggaugaaccaaacguggaguuaaggugccuaacuucuc
gcucaugagaccccauaaaagguguugguugauauugacagcaaucaacu
agcccugaaaauggauggcgcuuaagcgagagaccuauacuccgccguug
cgacaaggucguaacgaguaggaaggucguggcgguugcguugaaggcug
agcguaggcucggcuggagcuuccgucagugcagaucguaaugguaguag
caaauauucaaguucgauccuugaagacugaaguggagaaggguuccacg
ugaacaguaguuggaugugggucagucgauccuaagguacuggcgaacgc
cuuguaucaucgguggcgguccccgcuugucgaaagggaauaggguuaau
auucccuaacugagaugcaaagauugugugcacaagcgcgguaacgcauu
cgaacuugguuagucgcucaaagaccgagcuagaguuuucuucucuaguu
aaggaacggacucccuggaauugguucagccagagauggggacguuguuu
ccgaaaagcaccgcguggugucucgugcucuuugaacggcccuuaaaaca
ccaagggaggcuauuaauuugcacucaaucguaccgauauccgcauuagg
ucuccaaggugaacagccucuagucgauagaauaauguagguaagggaag
ucggcaaacuagauccguaacuucgggaaaaggauuggcuccagugguua
ccguacuggaaccgguacggacucagggaauccgacugucuaauuaaaac
agaggugacagaugguccuugcggacguugacugucacugauuucugccc
agugcucugaauguuaaaucguaguaauucgaguaagcgcggguaaacgg
cgggaguaacuaugacucucuuaagguagccaaaugccucgucauuuaau
uguugacgcgcaugaauggauuaacgagauuccuacugucccuaacuacu
uucuagcgaaaccacagccaagggaacgggcuuggcaaaaauagcgggga
aagaagacccuguugagcuugacucuaguuugacauugugaagagucaga
cucuuuacuuauucgguuaaaagagaauuucgaagcauuaagcggagcca
uuauggcaccgugacucuccucgaagacagugucaagcggggaguuugac
uggggcgguacaucuaucaaaucguaacguagguguccuaaggcgagcuc
agagaggacggaaaccucucguagagcaaaagggcaaaagcuugcuugau
cuugacuuucaguacgaguacagaccgcgaaagcguggccuaucgauccu
uuuaauccugauuguuucagguaagaggugucagaaaaguuaccacaggg
auaacuggcuuguggcagccaagcguccauagcgacguugcuuuuugauc
cuucgaugucggcucuuccuaucauugcgaagcagaauucgccaagcguu
ggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgug
agacagguuaguuuuacccuacuguugacuuguuauugcgaaaguaaucc
ugcuuaguacgagaggaacagcggguucaaacauuugguucauagacuug
aucgacagaucaauggucugaagcuaccauuugagagauuauaacugaac
gccucuaaguuagaaucucgccuugucaaggcgaaaauuuugcuucccgg
ugucgggaggcaucucuaucucguggcaacacgagagcuuaugcccuaug
uauggccuuggcgucguagugauucugcgacgcuugccaacgccagauca
cucugguucaaugucggggcgcuaaaucacuugcauacgacuuggugguc
aagguguuguauucaguagagcaguccuuuuauacugcgaucuguugaga
cuauccuuugauugauuuuugu

.........................<<<<<<.....<......>......
>>>>>.>.........<<....>>..<<<<<......<<.....>>....
.>>>>>..<<<..<<<<<<..<<<<.<<<<<...>>>>>..>>>>....>
>>>>>..<<<.<<<<<<..<<<<<<<<<<<<<.<<<<<.....<<<<...
...>>>>..............<<<.......>>>.....>>>>>>>>>>>
>>>>>>>...>>>>>>.>>>.......<<<<<<<........>>>>>>>.
....<<<<<..((((..>>>>>..>>>.......................
...........<<....>>...............<<<<....>>>>....
..............................<<<<<<<.<<<<<..<<<<<
<<<<<<<<<<<<<<<<<<..<<.<<<<<.<<<<...<...>..>>>>.>>
>..>>.>>..>>.>>>>>>>>>>>>.>>>>>>>>>.....>>>>>...>>
>>>>>..<<<<........>>>><<<<<<...<<.<<<<<.<<<<<..<<
<...<<<<......>>>>...>>>...<<....>>...<<<<<<<.....
>>>>>>>..<<<<<...<<<<<..>>>>>....>>>>><<<<<<<<<<.<
<<<<..>>>>>>>>>>>>.>>>...>>>>>.>>>>>.>>.<<.<..<<<<
<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>
>>..<<<<..<<.<<........>>>>.>>>>...>>>>>>>>>...<<.
......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<...
.>>>.><<<<<<<<<<..<<<.<<<<<<<<<...<<<....<<<....<<
<..>>>....>>>..>.>>...>>>>>>>...<<<<<<<<<.<......>
>>>>>.>>>>...>>>>>>>>>>>>>.>>..<<<<.<<<<<.....>>>>
>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<
<<......<..........<<<.<<<<<<<<<<..........>>>>>>>
>>>>>>..........))).>....>>>>>>.>>>>..>>>>>>><<<<<
<<<<...>>>>>>>>>....>>>>>>...<<<<<<..<<......<<<<<
<<<....>>>>>>>>...>>..>>>>>>........>>>>>><<.....<
<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<
....<<.....>>..>>>>>....((<<<<<<...<<<...<<<....>>
>.........<<<.<<...>>.>>>...>>>....>>...<<<<<.....
...>>>>>))<<<<.<<<<<<..<<<<<..>>>>><<<<<....>>>...
<.((<<<<<<..<<<<.<<<<<<<.<<<<<<<<<<...[[..>>>>>><.
..<<<<<<...<<<<<<....<<<<...>>>>....>>>>>>...>>>>.
>>....><<<<<<..>>>>>>>>>>...>>>>>>>.>>>>.........>
>>>>>...>>>......>>>>>>>>>>>>>>..>>.....<<......>>
>>>>>.<<<<.....>>>>..>>>>..<<<<<....<<<<.<<.<<....
.....<.....<<<<<....<<..>>.....>>>>><<.<<<<<<<<<.>
>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>
>..<<<<<<<....<<<<....>>>>......>>>>>>>...<<..<<<.
.<<<<<<.....<<....<<<.<....>.>>>....>>..>>>>..>>>>
><<<<<<.......>>>>>>........<...........<<<<.<....
.>.>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>.>>>>.
>>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.
<<......<<<<.<<<<<<..<<<<<.<<<<<<<<<.<<<<<<<<<<.>>
>>>>>>>>...<<<<<.....<<<<............))..<<<<.<<<<
<.>>>>>.>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<
<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<..
.<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<
<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......<<
<<<<..<<<<...))))>>>>>>>>>>..........>>>>..>>>>>>.
......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.
>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<
<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<...
.>>>.>>>>....>>..>>>.>>>>>.....<<<.<<<<..<<<..<.<<
<<<<...............>>>>>>.><<<<....<<<<....<<<<<<<
<<<]]..>>>>>..>>>>>...>>>>...>>>>.<<<<...<<<<<....
.......>>>>>...>>>>..>>>......>>>>.>>>...<<.<<<<<<
<<<.<<..<<<.......<<<<<<<....>>>>>>>......>>>....<
..<<<<...<<<<<<<<<<.....>>>>>>>>>>.>>>>...>.......
.......>>.>>>>>>>>>.>>.<<<...<.............>.<<<<<
<<<<.<<<.....<<<....<<<<<........>>>>>...>>>....>>
>...>>>.>>>>>>...>>>..

Receptor-Ligand Complex Structure

Structure summary

• PDB: 9cai High-Resolution Reconstruction of a C. elegans Ribosome Sheds Light on Evolutionary Dynamics and Tissue Specificity.
• Resolution: 2.59 Å
• Binding residue (original residue number in PDB): K4 L6 G7 F71 K73 T77 S89 R90 T91 H94 N95 Y97 R98 R101 R114 G117 A118 R119 H120 R121 A137 R142 F148 H149 D150 P158 H159 R160 T162 K163 R164 L167 T171 T172 A173 R174 Q175 N176 T177 H178 F179 A180
• Binding residue (residue number reindexed from 1): K3 L5 G6 F70 K72 T76 S88 R89 T90 H93 N94 Y96 R97 R100 R113 G116 A117 R118 H119 R120 A136 R141 F147 H148 D149 P157 H158 R159 T161 K162 R163 L166 T170 T171 A172 R173 Q174 N175 T176 H177 F178 A179

External links

• PDB: RCSB:9cai, PDBe:9cai, PDBj:9cai
• PDBsum: 9cai
• PubMed: 39209556
• UniProt: O44480|RL18A_CAEEL Large ribosomal subunit protein eL20 (Gene Name=rpl-20)