Structure of PDB 6u48 Chain CP Binding Site BS02

Receptor Information

>6u48 Chain CP (length=116) Species: 562 (Escherichia coli)

DKKSARIRRATRARRKLQELGATRLVVHRTPRHIYAQVIAPNGSEVLVAA
STVEKAIAEQLKYTGNKDAAAAVGKAVAERALEKGIKDVSFDRSGFQYHG
RVQALADAAREAGLQF

Ligand information

>6u48 Chain CB (length=118)

gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucag
aagugaaacgccguagcgccgaugguaguguggggucuccccaugcgaga
guagggaacugccaggca

<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>
..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>....
...>>...>>>>>>>>>.

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6u48 Structure of ribosome-bound azole-modified peptide phazolicin rationalizes its species-specific mode of bacterial translation inhibition.
• Resolution: 2.87 Å
• Binding residue (original residue number in PDB): K3 K4 R15 R25 H29 R30 T31 R33 H34 Y36 Q38 I40 G44 S45 V47 V54 E55 K63 Y64 N67 K68 Q98 H100 G101
• Binding residue (residue number reindexed from 1): K2 K3 R14 R24 H28 R29 T30 R32 H33 Y35 Q37 I39 G43 S44 V46 V53 E54 K62 Y63 N66 K67 Q97 H99 G100

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome
• GO:0008097 5S rRNA binding
• GO:0019843 rRNA binding

Biological Process

• GO:0002181 cytoplasmic translation
• GO:0006412 translation

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:6u48, PDBe:6u48, PDBj:6u48
• PDBsum: 6u48
• PubMed: 31594941
• UniProt: P0C018|RL18_ECOLI Large ribosomal subunit protein uL18 (Gene Name=rplR)