Structure of PDB 5mei Chain CM Binding Site BS02

Receptor Information
>5mei Chain CM (length=169) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QNPMRDLKIEKLVLNISVGESGDRLTRASKVLEQLSGQTPVQSKARYTVR
TFGIRRNEKIAVHVTVRGPKAEEILERGLKVKEYQLRDRNFSATGNFGFG
IDEHIDLGIKYDPSIGIFGMDFYVVMNRPGARVTRRKRCKGTVGNSHKTT
KEDTVSWFKQKYDADVLDK
Ligand information
>5mei Chain AS (length=121) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacugu
aguuaagcugguaagagccugaccgaguaguguagugggugaccauacgc
gaaacucaggugcugcaaucu
<<<<<<<<<....<<<<<<<<.....<<.<<<............>>>...
.>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>
.....>>>>>>>>>>>>>>>.
Receptor-Ligand Complex Structure
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PDB5mei Inhibition of Eukaryotic Translation by the Antitumor Natural Product Agelastatin A.
Resolution3.5 Å
Binding residue
(original residue number in PDB)		M9 Q43 T44 V46 V69 T70 R72 G135 R137 R141 K142 R143 V148 G149 N150 S151 H152
Binding residue
(residue number reindexed from 1)		M4 Q38 T39 V41 V64 T65 R67 G130 R132 R136 K137 R138 V143 G144 N145 S146 H147
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0019843 rRNA binding
Biological Process
GO:0000027 ribosomal large subunit assembly
GO:0002181 cytoplasmic translation
GO:0006412 translation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5mei, PDBe:5mei, PDBj:5mei
PDBsum5mei
PubMed28457705
UniProtQ3E757|RL11B_YEAST Large ribosomal subunit protein uL5B (Gene Name=RPL11B)

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