Structure of PDB 4w2f Chain CL Binding Site BS02

Receptor Information

>4w2f Chain CL (length=122) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

PTINQLVRKGREKVRKKSKVPALKGAPFRRGVCTVVRTVTPKKPNSALRK
VAKVRLTSGYEVTAYIPGEGHNLQEHSVVLIRGGRVKDLPGVRYHIVRGV
YDAAGVKDRKKSRSKYGTKKPK

Ligand information

InChI=1S/Mg/q+2

JLVVSXFLKOJNIY-UHFFFAOYSA-N

SMILES

Software	SMILES
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Mg+2]
CACTVS 3.341	[Mg++]

Formula

Mg

Name

MAGNESIUM ION

PDB chain

4w2f Chain CL Residue 201 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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PDB	4w2f Amicoumacin a inhibits translation by stabilizing mRNA interaction with the ribosome.
Resolution	2.4 Å
Binding residue (original residue number in PDB)	T67 G95 V96 R97 Y98
Binding residue (residue number reindexed from 1)	T63 G91 V92 R93 Y94
Annotation score	4

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0000049	tRNA binding
GO:0003735	structural constituent of ribosome
GO:0019843	rRNA binding

	Biological Process
GO:0006412	translation

	Cellular Component
GO:0005840	ribosome
GO:0015935	small ribosomal subunit
GO:1990904	ribonucleoprotein complex

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Biological Process

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Cellular Component

External links

PDB	RCSB:4w2f, PDBe:4w2f, PDBj:4w2f
PDBsum	4w2f
PubMed	25306919
UniProt	Q5SHN3\|RS12_THET8 Small ribosomal subunit protein uS12 (Gene Name=rpsL)

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