Structure of PDB 4v6x Chain CJ Binding Site BS02

Receptor Information
>4v6x Chain CJ (length=168) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ENPMRELRIRKLCLNICVGESGDRLTRAAKVLEQLTGQTPVFSKARYTVR
SFGIRRNEKIAVHCTVRGAKAEEILEKGLKVREYELRKNNFSDTGNFGFG
IQEHIDLGIKYDPSIGIYGLDFYVVLGRPGFSIADKKRRTGCIGAKHRIS
KEEAMRWFQQKYDGIILP
Ligand information
>4v6x Chain A7 (length=121) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaa
gcuaagcagggucgggccugguuaguacuuggaugggagaccgccuggga
auaccgggugcuguaggcuuu
<<<<<<<<<....<<<<<<<<.....<<<<<<............>>>>..
>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>..
..>>>>>>>>>>>>>>>>...
Receptor-Ligand Complex Structure
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PDB4v6x Structures of the human and Drosophila 80S ribosome.
Resolution5.0 Å
Binding residue
(original residue number in PDB)		M12 Q46 T47 V49 T73 R75 G138 S140 I141 K144 K145 R146 R147 C150 G152 A153 K154
Binding residue
(residue number reindexed from 1)		M4 Q38 T39 V41 T65 R67 G130 S132 I133 K136 K137 R138 R139 C142 G144 A145 K146
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding
GO:0008097 5S rRNA binding
GO:0019843 rRNA binding
GO:0031625 ubiquitin protein ligase binding
GO:1990948 ubiquitin ligase inhibitor activity
Biological Process
GO:0000027 ribosomal large subunit assembly
GO:0002181 cytoplasmic translation
GO:0006364 rRNA processing
GO:0006412 translation
GO:0006605 protein targeting
GO:0010628 positive regulation of gene expression
GO:0032092 positive regulation of protein binding
GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0034504 protein localization to nucleus
GO:0042273 ribosomal large subunit biogenesis
GO:0050821 protein stabilization
GO:1901796 regulation of signal transduction by p53 class mediator
GO:1901798 positive regulation of signal transduction by p53 class mediator
GO:1904667 negative regulation of ubiquitin protein ligase activity
GO:2000059 negative regulation of ubiquitin-dependent protein catabolic process
GO:2000435 negative regulation of protein neddylation
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005840 ribosome
GO:0016020 membrane
GO:0022625 cytosolic large ribosomal subunit
GO:0022626 cytosolic ribosome
GO:0032991 protein-containing complex
GO:0070062 extracellular exosome
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4v6x, PDBe:4v6x, PDBj:4v6x
PDBsum4v6x
PubMed23636399
UniProtP62913|RL11_HUMAN Large ribosomal subunit protein uL5 (Gene Name=RPL11)

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