Structure of PDB 9bh5 Chain CI Binding Site BS02

Receptor Information

>9bh5 Chain CI (length=213) Species: 6239 (Caenorhabditis elegans)

GRRPARCYRYIKNKPYPKSRFCRGVPDAKIRIFDLGNKRANVDTFPACVH
MMSNEREHLSSEALEAARICANKYMVKNCGKDGFHLRVRKHPFHVTRINK
MLSCAGADRLQTGMRGAYGKPQGLVARVDIGDILFSMRIKEGNVKHAIEA
FRRAKFKFPGRQIIVSSRKWGFTKWDREDYERMRAEGRLRSDGVGVQLQR
EHGPLTKWIENPI

Ligand information

>9bh5 Chain A5 (length=3022)

cucaaccugaacucagucgugauuacccgcugaacuuaagcauaucauuu
agcggaggaaaagaaacuaaaaaggauucccuuaguaacggcgagugaaa
cgggaagagcccagcgccgaaucgaucagucuuuggcugcuucgaaaugu
ggcguauagguguaaguuuccagcagugucguauguccgaaguccuuacg
auugaggccauaaaccagagagggugcgagccccguucuggauagcggca
cuguugguucgcuugcuccuuggagucggguugcuugaaagugcagccua
aagugggugauaaacuucaucuaaggcuaaauaucgacucgauugcgaua
gcgaacaaguaccgugagggaaaguugcaaaggacuuugaagagagaguu
caagagaacgugaaaucgcuggaguggaaccggagacaguugauuacgcc
gacggcguuggcugcucguucuagcccgacaguguugcgucuugcuggcg
guaguggguucguggcggcuagcguacgucggugugaaagucgacgacgu
uuccgacccgucuugaaacacggauugcggagugcuugucuacugcgagu
caaaggguguuaaaaccuugcggcgaaaugaaaguaaaggucagucucga
auuggccgacgugggaucugugugugcagcgcaccacggcccugugcgug
ucacuugugacugugcagagguugagcaguuggcaaacgacccgaaagau
ggugaacuaugccugagcaggaugaagccagaggaaacucugguggaagu
ccguaucgguucugacgugcaaaucgaucgauagacuuggguauaggggc
gaaagacuaaucgaaccaucuaguagcugguuccuuccgaaguuucccuc
aggauagcuggaucucaggcaguuauauucgguaaagcuaaugauuagag
gaaccuauucucaaacuuucaauggauaugaaguugcaguuucuuuagug
aacugucaacgugaaugcgagguccaagugggccauuuuugguaagcaga
acuggcgcugugggaugaaccaaacguggaguuaaggugccuaacuucuc
gcucaugagaccccauaaaagguguugguugauauugacagcaaucaacu
agcccugaaaauggauggcgcuuaagcgagagaccuauacuccgccguug
cgacaaggucguaacgaguaggaaggucguggcgguugcguugaaggcug
agcguaggcucggcuggagcuuccgucagugcagaucguaaugguaguag
caaauauucaaguucgauccuugaagacugaaguggagaaggguuccacg
ugaacaguaguuggaugugggucagucgauccuaagguacuggcgaacgc
cuuguaucaucgguggcgguccccgcuugucgaaagggaauaggguuaau
auucccuaacugagaugcaaagauugugugcacaagcgcgguaacgcauu
cgaacuugguuagucgcucaaagaccgagcuagaguuuucuucucuaguu
aaggaacggacucccuggaauugguucagccagagauggggacguuguuu
ccgaaaagcaccgcguggugucucgugcucuuugaacggcccuuaaaaca
ccaagggaggcuauuaauuugcacucaaucguaccgauauccgcauuagg
ucuccaaggugaacagccucuagucgauagaauaauguagguaagggaag
ucggcaaacuagauccguaacuucgggaaaaggauuggcuccagugguua
ccguacuggaaccgguacggacucagggaauccgacugucuaauuaaaac
agaggugacagaugguccuugcggacguugacugucacugauuucugccc
agugcucugaauguuaaaucguaguaauucgaguaagcgcggguaaacgg
cgggaguaacuaugacucucuuaagguagccaaaugccucgucauuuaau
uguugacgcgcaugaauggauuaacgagauuccuacugucccuaacuacu
uucuagcgaaaccacagccaagggaacgggcuuggcaaaaauagcgggga
aagaagacccuguugagcuugacucuaguuugacauugugaagagucaga
cucuuuacuuauucgguuaaaagagaauuucgaagcauuaagcggagcca
uuauggcaccgugacucuccucgaagacagugucaagcggggaguuugac
uggggcgguacaucuaucaaaucguaacguagguguccuaaggcgagcuc
agagaggacggaaaccucucguagagcaaaagggcaaaagcuugcuugau
cuugacuuucaguacgaguacagaccgcgaaagcguggccuaucgauccu
uuuaauccugauuguuucagguaagaggugucagaaaaguuaccacaggg
auaacuggcuuguggcagccaagcguccauagcgacguugcuuuuugauc
cuucgaugucggcucuuccuaucauugcgaagcagaauucgccaagcguu
ggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgug
agacagguuaguuuuacccuacuguugacuuguuauugcgaaaguaaucc
ugcuuaguacgagaggaacagcggguucaaacauuugguucauagacuug
aucgacagaucaauggucugaagcuaccauuugagagauuauaacugaac
gccucuaaguuagaaucucgccuugucaaggcgaaaauuuugcuucccgg
ugucgggaggcaucucuaucucguggcaacacgagagcuuaugcccuaug
uauggccuuggcgucguagugauucugcgacgcuugccaacgccagauca
cucugguucaaugucggggcgcuaaaucacuugcauacgacuuggugguc
aagguguuguauucaguagagcaguccuuuuauacugcgaucuguugaga
cuauccuuugauugauuuuugu

.........................<<<<<<.....<......>......
>>>>>.>.........<<....>>..<<<<<......<<.....>>....
.>>>>>..<<<..<<<<<<..<<<<.<<<<<...>>>>>..>>>>....>
>>>>>..<<<.<<<<<<..<<<<<<<<<<<<<.<<<<<.<...<<<<...
...>>>>..............<<<.......>>>..>..>>>>>>>>>>>
>>>>>>>...>>>>>>.>>>.......<<<<<<<........>>>>>>>.
....<<<<<..((((..>>>>>..>>>.......................
...........<<....>>...............<<<<....>>>>....
..............................<<<<<<<.<<<<<...<<<<
<<<<<<<<<<<<<<<<<<..<<.<<<<<.<<<<...<...>..>>>>.>>
>..>>.>>..>>.>>>>>>>>>>>>.>>>>>>>>......>>>>>...>>
>>>>>..<<<<........>>>><<<<<<...<<.<<<<<.<<<<<..<<
<...<<<<......>>>>...>>>...<<....>>...<<<<<<<.....
>>>>>>>..<<<<<...<<<<<..>>>>>....>>>>><<<<<<<<<<.<
<<<<..>>>>>>>>>>>>.>>>...>>>>>.>>>>>.>>.<<.<..<<<<
<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>
>>..<<<<..<<.<<........>>>>.>>>>...>>>>>>>>>...<<.
......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<...
.>>>.><<<<<<<<<<..<<<.<<<<<<<<<...<<<....<<<....<<
<..>>>....>>>..>.>>...>>>>>>>...<<<<<<<<<.<......>
>>>>>.>>>>...>>>>>>>>>>>>>.>>..<<<<.<<<<<.....>>>>
>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<
<<......<..........<<<.<<<<<<<<<<..........>>>>>>>
>>>>>>..........))).>....>>>>>>.>>>>..>>>>>>><<<<<
<<<<...>>>>>>>>>....>>>>>>...<<<<<<..<<......<<<<<
<<<....>>>>>>>>...>>..>>>>>>........>>>>>><<.....<
<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<
....<<.....>>..>>>>>....((<<<<<<...<<<...<<<....>>
>.........<<<.<<...>>.>>>...>>>....>>...<<<<<.....
...>>>>>))<<<<.<<<<<<..<<<<<..>>>>><<<<<....>>>...
<.((<<<<<<..<<<<.<<<<<<<.<<<<<<<<<<...[[..>>>>>><.
..<<<<<<...<<<<<<....<<<<...>>>>....>>>>>>...>>>>.
>>....><<<<<<..>>>>>>>>>>...>>>>>>>.>>>>.........>
>>>>>...>>>......>>>>>>>>>>>>>>..>>.....<<......>>
>>>>>.<<<<.....>>>>..>>>>..<<<<<....<<<<.<<.<<....
.....<.....<<<<<....<<..>>.....>>>>><<.<<<<<<<<<.>
>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>
>..<<<<<<<....<<<<....>>>>......>>>>>>>...<<..<<<.
.<<<<<<.....<<....<<<.<....>.>>>....>>..>>>>..>>>>
><<<<<<.......>>>>>>........<...........<<<<.<....
.>.>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>.>>>>.
>>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.
<<......<<<<.<<<<<<..<<<<<.<<<<<<<<<.<<<<<<<<<<.>>
>>>>>>>>...<<<<<.....<<<<............))..<<<<.<<<<
<.>>>>>.>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<
<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<..
.<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<
<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......<<
<<<<..<<<<...))))>>>>>>>>>>..........>>>>..>>>>>>.
......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.
>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<
<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<...
.>>>.>>>>....>>..>>>.>>>>>.....<<<.<<<<..<<<..<.<<
<<<<...............>>>>>>.><<<<....<<<<....<<<<<<<
<<<]]..>>>>>..>>>>>...>>>>...>>>>.<<<<...<<<<<....
.......>>>>>...>>>>..>>>......>>>>.>>>...<<.<<<<<<
<<<.<<..<<<.......<<<<<<<....>>>>>>>......>>>....<
..<<<<...<<<<<<<<<<.....>>>>>>>>>>.>>>>...>.......
.......>>.>>>>>>>>>.>>.<<<...<.............>.<<<<<
<<<<.<<<.....<<<....<<<<<........>>>>>...>>>....>>
>...>>>.>>>>>>...>>>..

Receptor-Ligand Complex Structure

Structure summary

• PDB: 9bh5 High-Resolution Reconstruction of a C. elegans Ribosome Sheds Light on Evolutionary Dynamics and Tissue Specificity.
• Resolution: 2.63 Å
• Binding residue (original residue number in PDB): R3 R4 A6 R7 C8 K13 N14 K15 P16 F22 K30 K39 R40 E63 A64 K74 R90 H92 F94 R98 I99 N100 R110 Q112 G114 M115 R116 A118 Y119 G120 R154 F157 K158 P160 R162 D193 G194 Q198
• Binding residue (residue number reindexed from 1): R2 R3 A5 R6 C7 K12 N13 K14 P15 F21 K29 K38 R39 E62 A63 K73 R89 H91 F93 R97 I98 N99 R109 Q111 G113 M114 R115 A117 Y118 G119 R153 F156 K157 P159 R161 D192 G193 Q197

External links

• PDB: RCSB:9bh5, PDBe:9bh5, PDBj:9bh5
• PDBsum: 9bh5
• PubMed: 39209556
• UniProt: Q09533|RL10_CAEEL Large ribosomal subunit protein uL16 (Gene Name=rpl-10)