Structure of PDB 5mei Chain CG Binding Site BS02

Receptor Information
>5mei Chain CG (length=296) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AFQKDAKSSAYSSRFQTPFRRRREGKTDYYQRKRLVTQHKAKYNTPKYRL
VVRFTNKDIICQIISSTITGDVVLAAAYSHELPRYGITHGLTNWAAAYAT
GLLIARRTLQKLGLDETYKGVEEVEGEYELTEAVEDGPRPFKVFLDIGLQ
RTTTGARVFGALKGASDGGLYVPHSENRFPGWDFETEEIDPELLRSYIFG
GHVSQYMEELADDDEERFSELFKGYLADDIDADSLEDIYTSAHEAIRADP
AFKPTEKKFTKEQYAAESKKYRQTKLSKEERAARVAAKIAALAGQQ
Ligand information
>5mei Chain AS (length=121) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacugu
aguuaagcugguaagagccugaccgaguaguguagugggugaccauacgc
gaaacucaggugcugcaaucu
<<<<<<<<<....<<<<<<<<.....<<.<<<............>>>...
.>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>
.....>>>>>>>>>>>>>>>.
Receptor-Ligand Complex Structure
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PDB5mei Inhibition of Eukaryotic Translation by the Antitumor Natural Product Agelastatin A.
Resolution3.5 Å
Binding residue
(original residue number in PDB)		A2 K8 S10 S13 S14 F16 T18 F20 R21 R22 R24 T28 Y30 R33 R50 R54 T56 N57 K58 I61 Q63 I65 I69 T70 D72 V74 Y79 G91 N94 W95 Q151 R152 T154 T155 G156 R158 Y198 H203 Y207 E210 E221 K224 T256 K259 F260 Y265 A266 E268 S269 K270 Y272 Q274 K276 L277 K279 R282 R285
Binding residue
(residue number reindexed from 1)		A1 K7 S9 S12 S13 F15 T17 F19 R20 R21 R23 T27 Y29 R32 R49 R53 T55 N56 K57 I60 Q62 I64 I68 T69 D71 V73 Y78 G90 N93 W94 Q150 R151 T153 T154 G155 R157 Y197 H202 Y206 E209 E220 K223 T255 K258 F259 Y264 A265 E267 S268 K269 Y271 Q273 K275 L276 K278 R281 R284
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding
GO:0008097 5S rRNA binding
GO:0019843 rRNA binding
Biological Process
GO:0000027 ribosomal large subunit assembly
GO:0002181 cytoplasmic translation
GO:0006412 translation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5mei, PDBe:5mei, PDBj:5mei
PDBsum5mei
PubMed28457705
UniProtP26321|RL5_YEAST Large ribosomal subunit protein uL18 (Gene Name=RPL5)

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