Structure of PDB 4v6x Chain CD Binding Site BS02

Receptor Information
>4v6x Chain CD (length=289) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NKAYFKRYQVKFRRRREGKTDYYARKRLVIQDKNKYNTPKYRMIVRVTNR
DIICQIAYARIEGDMIVCAAYAHELPKYGVKVGLTNYAAAYCTGLLLARR
LLNRFGMDKIYEGQVEVTGDEYNVESIDGQPGAFTCYLDAGLARTTTGNK
VFGALKGAVDGGLSIPHSTKRFPGYDSESKEFNAEVHRKHIMGQNVADYM
RYLMEEDEDAYKKQFSQYIKNSVTPDMMEEMYKKAHAAIRENPVYEKKPK
KEVKKKRWNRPKMSLAQKKDRVAQKKASFLRAQERAAES
Ligand information
>4v6x Chain A7 (length=121) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaa
gcuaagcagggucgggccugguuaguacuuggaugggagaccgccuggga
auaccgggugcuguaggcuuu
<<<<<<<<<....<<<<<<<<.....<<<<<<............>>>>..
>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>..
..>>>>>>>>>>>>>>>>...
Receptor-Ligand Complex Structure
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PDB4v6x Structures of the human and Drosophila 80S ribosome.
Resolution5.0 Å
Binding residue
(original residue number in PDB)		K10 F13 K14 Y16 V18 R21 R22 R24 T28 Y30 R33 I52 R54 T56 N57 I61 Q63 I69 E70 G71 D72 M73 I74 G91 N94 R152 T154 T155 N157 K158 P181 Y207 F223 Q225 Y253 K258 K259 E260 K262 K263 W266 K270 L273 K276 R279 V280
Binding residue
(residue number reindexed from 1)		K2 F5 K6 Y8 V10 R13 R14 R16 T20 Y22 R25 I44 R46 T48 N49 I53 Q55 I61 E62 G63 D64 M65 I66 G83 N86 R144 T146 T147 N149 K150 P173 Y199 F215 Q217 Y245 K250 K251 E252 K254 K255 W258 K262 L265 K268 R271 V272
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003730 mRNA 3'-UTR binding
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding
GO:0008097 5S rRNA binding
GO:0019843 rRNA binding
GO:0031625 ubiquitin protein ligase binding
GO:0048027 mRNA 5'-UTR binding
GO:1990948 ubiquitin ligase inhibitor activity
Biological Process
GO:0000027 ribosomal large subunit assembly
GO:0002181 cytoplasmic translation
GO:0006364 rRNA processing
GO:0006412 translation
GO:0010628 positive regulation of gene expression
GO:0042273 ribosomal large subunit biogenesis
GO:0045727 positive regulation of translation
GO:0050821 protein stabilization
GO:1901796 regulation of signal transduction by p53 class mediator
GO:1904667 negative regulation of ubiquitin protein ligase activity
GO:2000059 negative regulation of ubiquitin-dependent protein catabolic process
GO:2000435 negative regulation of protein neddylation
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005829 cytosol
GO:0005840 ribosome
GO:0005925 focal adhesion
GO:0016020 membrane
GO:0022625 cytosolic large ribosomal subunit
GO:0022626 cytosolic ribosome
GO:0032991 protein-containing complex
GO:0070062 extracellular exosome
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4v6x, PDBe:4v6x, PDBj:4v6x
PDBsum4v6x
PubMed23636399
UniProtP46777|RL5_HUMAN Large ribosomal subunit protein uL18 (Gene Name=RPL5)

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