Structure of PDB 8bqs Chain CB Binding Site BS02

Receptor Information

>8bqs Chain CB (length=285) Species: 312017 (Tetrahymena thermophila SB210)

AESNDATSICLESISGTIKGLQKANYVVEHNPNLTSEEKKHLKQFLVYRY
NPADPHDQPKYVSYWCDIKKFPPMFLDAILYIKNELDPTLSIRRSCREGI
CGSCAVNCDGLHTLACISGFNRDLSKPTIITPLGHMFILKDLVVDMTNFY
AQYKMIEPYLKRKTPKPDANKEYPQSPEQRALLDGLYECVLCAACSTSCP
SYWWHPDRYLGPAILQQAYRWIVDSRDEYTQERIERIAEDVRLDDCQQIG
MCSFTCPKGLNPQLSLKNLMDMVKDFRQKRIEQEV

Ligand information

• Ligand ID: SF4
• InChI: InChI=1S/4Fe.4S
• InChIKey: LJBDFODJNLIPKO-UHFFFAOYSA-N
• SMILES:
  OpenEye OEToolkits 2.0.7: [S]12[Fe]3[S]4[Fe]1[S]5[Fe]2[S]3[Fe]45
  CACTVS 3.385: S1[Fe]S[Fe]1.S2[Fe]S[Fe]2
• Formula: Fe4 S4
• Name: IRON/SULFUR CLUSTER
• PDB chain: 8bqs Chain CB Residue 1001

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8bqs Structural basis of mitochondrial membrane bending by I-II-III2-IV2 supercomplex
• Resolution: 2.9 Å
• Binding residue (original residue number in PDB): C215 V216 L217 C218 A219 C221 A239 C282
• Binding residue (residue number reindexed from 1): C189 V190 L191 C192 A193 C195 A213 C256
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 1.3.5.1: succinate dehydrogenase.

Gene Ontology

Molecular Function

• GO:0008177 succinate dehydrogenase (quinone) activity
• GO:0009055 electron transfer activity
• GO:0016491 oxidoreductase activity
• GO:0051536 iron-sulfur cluster binding
• GO:0051537 2 iron, 2 sulfur cluster binding
• GO:0051538 3 iron, 4 sulfur cluster binding

Biological Process

• GO:0006099 tricarboxylic acid cycle
• GO:0009060 aerobic respiration
• GO:0022904 respiratory electron transport chain

Cellular Component

• GO:0005743 mitochondrial inner membrane

External links

• PDB: RCSB:8bqs, PDBe:8bqs, PDBj:8bqs
• PDBsum: 8bqs
• UniProt: I7M403