Structure of PDB 8z9h Chain C Binding Site BS02

Receptor Information
>8z9h Chain C (length=748) Species: 126796 (Thogoto virus (isolate SiAr 126)) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ESECTLRALVEEYNGACKEAPKEMSKQFTDYNTFKRYTTSKKDHAPQMRL
VYSVRKPWPISMTPSKEIPLVFNGTKLKDTILDLGESKRTRANIVVPDYW
SKYGSQTSLEVVNAILYAEDLKVQRFFSTEWGEIRYGRMLPFRKPVQACP
TIEEVNPASIPHTLLQVFCPQYTTLDSKRKAHMGAVEKLKRVMEPICKVQ
TQESAVHIARSLIDSNKKWLPTVVDHTPRTAEMAHFLCSKYHYVHTNTQD
LSDTRSIDNLCGELVKRSLKCRCPKETLVANLDKITIQGRPMREVLADHD
GELPYLGICRVAMGLSTHHTMKIRSTKFSILNSDHPRIEVKKVFSLSPDV
QVTIPYRRFKGKAKVYFQNDQIQGYFSCTDRQIDEIKISAPKNAPLLEPL
LDICYYGSFIEPGFEQTFGFYPAGKREFVDSFFMHHSKDHKAFLIHMGLD
KDLSLPLSPELNWKEPALSKVCRVTELDSTVQPYTSATREFVLGETLNVY
TQHENGLELLICPTEIRSTRGPLPPGTNLSGSEFIDIYQDPFSRAKSLLK
STILHAERCKEFVGNMLEEYQDPAETTVQSLVPINTWGKSAKRKLQEEIT
SDPDWHQCPRKRAKMSYLAIIAGSIQDRDKKQTNVPRAFMLRGSQIEYDM
KATRGLVVDTTNRIIVGGETVLREGKGGPEGYVQTGVFEEQPRCYLVDTP
DHGLSMGLSRFCVHSQGRYFQYEKKISIWEETDNIKATIDSQRDLKRR
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB8z9h Cryo-EM structures of Thogoto virus polymerase reveal unique RNA transcription and replication mechanisms among orthomyxoviruses
Resolution2.7 Å
Binding residue
(original residue number in PDB)		R43 T45 K48 K49 D50 P53 Q54
Binding residue
(residue number reindexed from 1)		R36 T38 K41 K42 D43 P46 Q47
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Biological Process
GO:0006370 7-methylguanosine mRNA capping
GO:0075526 cap snatching
Cellular Component
GO:0042025 host cell nucleus
GO:0044423 virion component

View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8z9h, PDBe:8z9h, PDBj:8z9h
PDBsum8z9h
PubMed38816392
UniProtQ9YNA4|PB2_THOGV Polymerase basic protein 2 (Gene Name=Segment)

[Back to BioLiP]