Structure of PDB 8yte Chain C Binding Site BS02

Receptor Information
>8yte Chain C (length=98) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEF
LEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMD
Ligand information
Ligand IDGM1
InChIInChI=1S/C2H6N2O/c3-1-2(4)5/h1,3H2,(H2,4,5)
InChIKeyBEBCJVAWIBVWNZ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0C(C(=O)N)N
ACDLabs 10.04O=C(N)CN
CACTVS 3.341NCC(N)=O
FormulaC2 H6 N2 O
NameAMINOMETHYLAMIDE;
GLYCINAMID
ChEMBLCHEMBL86954
DrugBankDB03636
ZINCZINC000035874641
PDB chain8yte Chain D Residue 101 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8yte Discovery and Hit to Lead Optimization of Macrocyclic Peptides as Novel Tropomyosin Receptor Kinase A Antagonists.
Resolution2.26 Å
Binding residue
(original residue number in PDB)		L313 R314
Binding residue
(residue number reindexed from 1)		L31 R32
Annotation score1
External links
PDB RCSB:8yte, PDBe:8yte, PDBj:8yte
PDBsum8yte
PubMed38950284
UniProtP04629|NTRK1_HUMAN High affinity nerve growth factor receptor (Gene Name=NTRK1)

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