Structure of PDB 8w8o Chain C Binding Site BS02

Receptor Information
>8w8o Chain C (length=1107) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MEIKRFGRIREVIPLPPLTEIQVESYRRALQADVPPEKRENVGIQAAFRE
TFPIEEGLVLDFLEYRLGEPPFPQDECREKDLTYQAPLYARLQLIHKDTG
LIKEDEVFLGHIPLMTEDGSFIINGADRVIVSQIHRSPGVYFTPDPARPG
RYIASIIPLPKRGPWIDLEVEPNGVVSMKVNKRKFPLVLLLRVLGYDQET
LARELGAYGELVQGLMDESVFAMRPEEALIRLFTLLRPGDPPKRDKAVAY
VYGLIADPRRYDLGEAGRYKAEEKLGIRLSGRTLARFEDGEFKDEVFLPT
LRYLFALTAGVPGHEVDDIDHLGNRRIRTVGELMTDQFRVGLARLARGVR
ERMLMGSTPAKLVNSRPLEAAIREFFSRSQLSQFKDETNPLSSLRHKRRI
SALGPGGLTRERAGFDVRDVHRTHYGRICPVETPEGANIGLITSLAAYAR
VDELGFIRTPYRRVVGGVVTDEVVYMTATEEDRYTIAQANTPLEGNRIAA
ERVVARRKGEPVIVSPEEVEFMDVSPKQVFSVNTNLIPFLEHDDANRALM
GSNMQTQAVPLIRAQAPVVMTGLEERVVRDSLAALYAEEDGEVAKVDGNR
IVVRYEDGRLVEYPLRRFYRSNQGTALDQRPRVVVGQRVRKGDLLADGPA
SENGFLALGQNVLVAIMPFDGYNFEDAIVISEELLKRDFYTSIHIERYEI
EARDTKLGPERITRDIPHLSEAALRDLDEEGVVRIGAEVKPGDILVGRTS
FKGESEPTPEERLLRSIFGEKARDVKDTSLRVPPGEGGIVVRTVRLRRGD
GVELKPGVREVVRVYVAQKRKLQVGDKLANRHGNKGVVAKILPVEDMPHL
PDGTPVDVILNPLGVPSRMNLGQILETHLGLAGYFLGQRYISPIFDGAKE
PEIKELLAQAFEVYFGKRKGEGFGVDKREVEVLRRAEKLGLVTPGKTPEE
QLKELFLQGKVVLYDGRTGEPIEGPIVVGQMFIMKLYHMVEDKMHARSTG
PYSLITQQPLGGKAQFGGQRFGEMEVWALEAYGAAHTLQEMLTLKSDDIE
GRNAAYEAIIKGEDVPEPSVPESFRVLVKELQALALDVQTLDEKDNPVDI
FEGLASK
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8w8o Nanopore tweezers show fractional-nucleotide translocation in sequence-dependent pausing by RNA polymerase.
Resolution2.512 Å
Binding residue
(original residue number in PDB)		R142 K167 P170 W171 R243 R266 I325 D326 L418 R422 V427
Binding residue
(residue number reindexed from 1)		R136 K161 P164 W165 R237 R260 I319 D320 L408 R412 V417
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0034062 5'-3' RNA polymerase activity
Biological Process
GO:0006351 DNA-templated transcription
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8w8o, PDBe:8w8o, PDBj:8w8o
PDBsum8w8o
PubMed38990947
UniProtQ8RQE9|RPOB_THET8 DNA-directed RNA polymerase subunit beta (Gene Name=rpoB)

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