Structure of PDB 8t3m Chain C Binding Site BS02

Receptor Information
>8t3m Chain C (length=296) Species: 10116 (Rattus norvegicus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LSCIDTCEKNSVLEVIAYSSSETPNRHDMLLVEPLNRLLQDKWDRFVKRI
FYFNFFVYCLYMIIFTAAAYYRPPPYVGDYFRVTGEILSVSGGVYFFFRG
IQYFLQRRPSLKSLFVDSYSEILFFVQSLFMLVSVVLYFSQRKEYVASMV
FSLAMGWTNMLYYTRGFQQMGIYAVMIEKMILRDLCRFMFVYLVFLFGFS
TAVVTLIEDGKYNSLYSTCLELFKFTIGMGDLEFTENYDFKAVFIILLLA
YVILTYILLLNMLIALMGETVNKIAQESKNIWKLQRAITILDTEKS
Ligand information
Ligand IDNKN
InChIInChI=1S/C17H35O7P/c1-2-3-4-5-6-7-8-9-10-11-12-13-17(19)23-14-16(18)15-24-25(20,21)22/h16,18H,2-15H2,1H3,(H2,20,21,22)/t16-/m1/s1
InChIKeyFAZBDRGXCKPVJU-MRXNPFEDSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.7.0CCCCCCCCCCCCCC(=O)OC[C@H](COP(=O)(O)O)O
CACTVS 3.370CCCCCCCCCCCCCC(=O)OC[CH](O)CO[P](O)(O)=O
ACDLabs 12.01O=P(OCC(O)COC(=O)CCCCCCCCCCCCC)(O)O
OpenEye OEToolkits 1.7.0CCCCCCCCCCCCCC(=O)OCC(COP(=O)(O)O)O
CACTVS 3.370CCCCCCCCCCCCCC(=O)OC[C@@H](O)CO[P](O)(O)=O
FormulaC17 H35 O7 P
Name(2R)-2-hydroxy-3-(phosphonooxy)propyl tetradecanoate;
14:0 LPA;
myristoyl lysophosphatidic acid
ChEMBLCHEMBL1615121
DrugBank
ZINC
PDB chain8t3m Chain C Residue 801 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8t3m Structural basis of TRPV1 modulation by endogenous bioactive lipids.
Resolution3.5 Å
Binding residue
(original residue number in PDB)		Y511 S512 L515 F543 M547 T550 Y554 E570
Binding residue
(residue number reindexed from 1)		Y119 S120 L123 F151 M155 T158 Y162 E178
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
Biological Process
GO:0006811 monoatomic ion transport
GO:0055085 transmembrane transport
Cellular Component
GO:0016020 membrane

View graph for
Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8t3m, PDBe:8t3m, PDBj:8t3m
PDBsum8t3m
PubMed38698206
UniProtO35433|TRPV1_RAT Transient receptor potential cation channel subfamily V member 1 (Gene Name=Trpv1)

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