Structure of PDB 8skt Chain C Binding Site BS02
Receptor Information
>8skt Chain C (length=337) Species:
10090
(Mus musculus) [
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DKLKKVLDKLRLKRKDISEAAETVNKVVERLLRRMQSEFKGVEQLNTGSY
YEHVKISAPNEFDVMFKLEVPRIELQEYYETGAFYLVKFPLSHFVLSATK
MLSKFRKIIKEEVKEIKDIDVSVEKEKPGSPAVTLLIRNPEEISVDIILA
LESKGSWPISTKEGLPIQGWLGTKVRTNLRREPFYLVPKQGETWRLSFSH
TEKYILNNHGIEKTCCESSGAKCCRKECLKLMKYLLEQLKKEFQELDAFC
SYHVKTAIFHMWTQDPQDSQWDPRNLSSCFDKLLAFFLECLRTEKLDHYF
IPKFNLFSQELIDRKSKEFLSKKIEYERNNGFPIFDK
Ligand information
>8skt Chain I (length=18) [
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atctgtacatgtacagat
Receptor-Ligand Complex Structure
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PDB
8skt
Structure of ternary complex of mouse cGAS with dsDNA and bound ATP with 5 mM Mn2+
Resolution
2.69 Å
Binding residue
(original residue number in PDB)
R158 L159 K160 R161 H203 K395
Binding residue
(residue number reindexed from 1)
R11 L12 K13 R14 H53 K226
Enzymatic activity
Enzyme Commision number
2.7.7.86
: cyclic GMP-AMP synthase.
External links
PDB
RCSB:8skt
,
PDBe:8skt
,
PDBj:8skt
PDBsum
8skt
PubMed
38740774
UniProt
Q8C6L5
|CGAS_MOUSE Cyclic GMP-AMP synthase (Gene Name=Cgas)
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