Structure of PDB 8hsj Chain C Binding Site BS02

Receptor Information

>8hsj Chain C (length=361) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

RLVKGYLEISQDGYGFLTENLHNLESRVAIVSAGLIKQYALRAGDYVVGQ
ARPPRENERYATLLKVEAVNNLDPEAAKNRPRFDELTPQFPDRQIRLETT
PDELSTRVIDLLAPIGRGQRGLIVAPPKAGKTTLLKKIANAVLKNEPDIK
VIVLLIDERPEEVTDFRESVQGAEVIASTFDEPPQNHIRVAEFVHERAKR
IVEEGGHVMILLDSITRLARANNLVTPPTGRTLSGGLDSAALYFPKRFLG
AARNIRGGGSLTILATALVETGSRMDDVIFEEFKGTGNMELHLSRRLEER
RIFPAIDILKSGTRREELLLGEEVTHKMWLLRKVLADMDPAEAMEMLLAR
LARTKNNKEFL

Ligand information

Ligand ID

InChI

InChI=1S/Mg/q+2

InChIKey

JLVVSXFLKOJNIY-UHFFFAOYSA-N

SMILES

Software	SMILES
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Mg+2]
CACTVS 3.341	[Mg++]

Formula

Name

MAGNESIUM ION

PDB chain

8hsj Chain C Residue 1001 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	8hsj Structural basis of the transcription termination factor Rho engagement with transcribing RNA polymerase from Thermus thermophilus.
Resolution	3.6 Å
Binding residue (original residue number in PDB)	T191 E217 E221
Binding residue (residue number reindexed from 1)	T132 E158 E162
Annotation score	1

Enzymatic activity

Enzyme Commision number

3.6.4.-

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0004386	helicase activity
GO:0005524	ATP binding
GO:0008186	ATP-dependent activity, acting on RNA
GO:0016787	hydrolase activity
GO:0016887	ATP hydrolysis activity

	Biological Process
GO:0006353	DNA-templated transcription termination

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Molecular Function

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Biological Process

External links

PDB	RCSB:8hsj, PDBe:8hsj, PDBj:8hsj
PDBsum	8hsj
PubMed	36753546
UniProt	Q5SJE9

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