Structure of PDB 8hcd Chain C Binding Site BS02

Receptor Information
>8hcd Chain C (length=227) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TLPHGHMQTLIFLDLEATGLPSSRPEVTELCLLAVHRRALENTSISQGHP
PPVPRPPRVVDKLSLCIAPGKACSPGASEITGLSKAELEVQGRQRFDDNL
AILLRAFLQRQPQPCCLVAHNGDRYDFPLLQTELARLSTPSPLDGTFCVD
SIAALKALEQASSPRKSYSLGSIYTRLYWQAPTDSHTAEGDVLTLLSICQ
WKPQALLQWVDEHARPFSTVKPMYGTP
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain8hcd Chain C Residue 302 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8hcd Molecular insight into the specific enzymatic properties of TREX1 revealing the diverse functions in processing RNA and DNA/RNA hybrids.
Resolution2.0 Å
Binding residue
(original residue number in PDB)		D18 E20 D200
Binding residue
(residue number reindexed from 1)		D14 E16 D191
Annotation score4
Enzymatic activity
Enzyme Commision number 3.1.11.2: exodeoxyribonuclease III.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0008408 3'-5' exonuclease activity

View graph for
Molecular Function
External links
PDB RCSB:8hcd, PDBe:8hcd, PDBj:8hcd
PDBsum8hcd
PubMed37870446
UniProtQ91XB0|TREX1_MOUSE Three-prime repair exonuclease 1 (Gene Name=Trex1)

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