Structure of PDB 8g5x Chain C Binding Site BS02

Receptor Information

>8g5x Chain C (length=328) Species: 676032 (Francisella cf. tularensis subsp. novicida 3523)

MNRKVALEAVRVTELAALASWSQMGRGDKIAADQAAVDAMRKALNEVDID
GTVVIGEGELDEAPMLYIGEKVGAGGCEVDIALDPLEGTTITSKGGANAL
TVLAMADKGGFLNAPDVYMQKIAVGGINAPKGIVDLDDSVTNNLKRIAEF
KGVHMSALVVCTMDRPRHEHIIKEARECGARVILINDGDVSGVIATATEN
SGIDVYIGTGGAPEGVLAAAALKCLGGQMQARLIFNDEEEIKRAHRLGIT
DLNKKYDIDDLASGDIVFAATGVTDGNMLQGVKRVNSTRRGSYAVTHSVV
MRSTTKTVRHITAEHSFDFKEGIEKFMS

Ligand information

• Ligand ID: MN
• InChI: InChI=1S/Mn/q+2
• InChIKey: WAEMQWOKJMHJLA-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mn+2]
  CACTVS 3.341: [Mn++]
• Formula: Mn
• Name: MANGANESE (II) ION
• DrugBank: DB06757
• PDB chain: 8g5x Chain C Residue 606

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8g5x New structures of Class II Fructose-1,6-Bisphosphatase from Francisella tularensis provide a framework for a novel catalytic mechanism for the entire class.
• Resolution: 2.2 Å
• Binding residue (original residue number in PDB): D84 L86 E87
• Binding residue (residue number reindexed from 1): D84 L86 E87
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 3.1.3.11: fructose-bisphosphatase.

Gene Ontology

Molecular Function

• GO:0016787 hydrolase activity
• GO:0042132 fructose 1,6-bisphosphate 1-phosphatase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006071 glycerol metabolic process
• GO:0006094 gluconeogenesis
• GO:0030388 fructose 1,6-bisphosphate metabolic process

Cellular Component

• GO:0005829 cytosol

External links

• PDB: RCSB:8g5x, PDBe:8g5x, PDBj:8g5x
• PDBsum: 8g5x
• PubMed: 37352301
• UniProt: Q5NEJ8