Structure of PDB 8fpl Chain C Binding Site BS02

Receptor Information
>8fpl Chain C (length=256) Species: 10116 (Rattus norvegicus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKL
TIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFS
KPFMSLGISIMIKKPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVF
DKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQRKP
CDTMKVGGNLDSKGYGIATPKGSSLGTPVNLAVLKLSEQGVLDKLKNKWW
YDKGEC
Ligand information
Ligand IDY4Y
InChIInChI=1S/C9H8N4O4/c10-3-4-1-5-6(2-7(4)13(16)17)12-9(15)8(14)11-5/h1-2H,3,10H2,(H,11,14)(H,12,15)
InChIKeyDWQWOEGFPYFGFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 2.0.7c1c(c(cc2c1NC(=O)C(=O)N2)N(=O)=O)CN
CACTVS 3.385NCc1cc2NC(=O)C(=O)Nc2cc1[N](=O)=O
ACDLabs 12.01O=N(=O)c1cc2NC(=O)C(=O)Nc2cc1CN
FormulaC9 H8 N4 O4
Name6-(aminomethyl)-7-nitro-1,4-dihydroquinoxaline-2,3-dione
ChEMBL
DrugBank
ZINC
PDB chain8fpl Chain C Residue 901 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8fpl The open gate of the AMPA receptor forms a Ca 2+ binding site critical in regulating ion transport.
Resolution2.81 Å
Binding residue
(original residue number in PDB)		E402 Y450 P478 T480 R485 E705 Y732
Binding residue
(residue number reindexed from 1)		E10 Y58 P86 T88 R93 E188 Y215
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
GO:0015276 ligand-gated monoatomic ion channel activity
GO:0038023 signaling receptor activity
Biological Process
GO:0006811 monoatomic ion transport
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8fpl, PDBe:8fpl, PDBj:8fpl
PDBsum8fpl
PubMed38409505
UniProtP19491|GRIA2_RAT Glutamate receptor 2 (Gene Name=Gria2)

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