Structure of PDB 8fgw Chain C Binding Site BS02

Receptor Information
>8fgw Chain C (length=1342) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MKRIFSLLEKTWLGAPIQFAWQKTSGNYLAVTGADYIVKIFDRHGQKRSE
INLPGNCVAMDWDKDGDVLAVIAEKSSCIYLWDANTNKTSQLDNGMRDQM
SFLLWSKVGSFLAVGTVKGNLLIYNHQTSRKIPVLGKHTKRITCGCWNAE
NLLALGGEDKMITVSNQEGDTIRQTQVRSEPSNMQFFLMKMDDRTSAAES
MISVVLGKKTLFFLNLNEPDNPADLEFQQDFGNIVCYNWYGDGRIMIGFS
CGHFVVISTHTGELGQEIFQARNHKDNLTSIAVSQTLNKVATCGDNCIKI
QDLVDLKDMYVILNLDEENKGLGTLSWTDDGQLLALSTQRGSLHVFLTKL
PILGDACSTRIAYLTSLLEVTVANPVEGELPITVSVDVEPNFVAVGLYHL
AVGMNNRAWFYVLGENAVKKLKDMEYLGTVASICLHSDYAAALFEGKVQL
HLIESEILDAQEERETRLFPAVDDKCRILCHALTSDFLIYGTDTGVVQYF
YIEDWQFVNDYRHPVSVKKIFPDPNGTRLVFIDEKSDGFVYCPVNDATYE
IPDFSPTIKGVLWENWPMDKGVFIAYDDDKVYTYVFHKDTIQGAKVILAG
STKVPFAHKPLLLYNGELTCQTQSGKVNNIYLSTHGFLSNLKDTGPDELR
PMLAQNLMLKRFSDAWEMCRILNDEAAWNELARACLHHMEVEFAIRVYRR
IGNVGIVMSLEQIKGIEDYNLLAGHLAMFTNDYNLAQDLYLASSCPIAAL
EMRRDLQHWDSALQLAKHLAPDQIPFISKEYAIQLEFAGDYVNALAHYEK
GITGDNKEHDEACLAGVAQMSIRMGDIRRGVNQALKHPSRVLKRDCGAIL
ENMKQFSEAAQLYEKGLYYDKAASVYIRSKNWAKVGDLLPHVSSPKIHLQ
YAKAKEADGRYKEAVVAYENAKQWQSVIRIYLDHLNNPEKAVNIVRETQS
LDGAKMVARFFLQLGDYGSAIQFLVMSKCNNEAFTLAQQHNKMEIYADII
GSEDTTNEDYQSIALYFEGEKRYLQAGKFFLLCGQYSRALKHFLKCPSSE
DNVAIEMAIETVGQAKDELLTNQLIDHLLGENDGMPKDAKYLFRLYMALK
QYREAAQTAIIIAREEQSAGNYRNAHDVLFSMYAELKSQKIKIPSEMATN
LMILHSYILVKIHVKNGDHMKGARMLIRVANNISKFPSHIVPILTSTVIE
CHRAGLKNSAFSFAAMLMRPEYRSKIDAKYKKKIEGMVRRPDISEIEEAT
TPCPFCKFLLPECELLCPGCKNSIPYCIATGRHMLKDDWTVCPHCDFPAL
YSELKIMLNTESTCPMCSERLNAAQLKKISDCTQYLRTEEEL
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain8fgw Chain C Residue 1402 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8fgw Human IFT-A complex structures provide molecular insights into ciliary transport.
Resolution3.7 Å
Binding residue
(original residue number in PDB)		C1253 C1267 C1270
Binding residue
(residue number reindexed from 1)		C1253 C1267 C1270
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005515 protein binding
Biological Process
GO:0000902 cell morphogenesis
GO:0001701 in utero embryonic development
GO:0007224 smoothened signaling pathway
GO:0008406 gonad development
GO:0030030 cell projection organization
GO:0030326 embryonic limb morphogenesis
GO:0031076 embryonic camera-type eye development
GO:0035721 intraciliary retrograde transport
GO:0042471 ear morphogenesis
GO:0043113 receptor clustering
GO:0048701 embryonic cranial skeleton morphogenesis
GO:0050877 nervous system process
GO:0055123 digestive system development
GO:0060271 cilium assembly
GO:0060831 smoothened signaling pathway involved in dorsal/ventral neural tube patterning
GO:0061055 myotome development
GO:0065003 protein-containing complex assembly
GO:1903441 protein localization to ciliary membrane
Cellular Component
GO:0001750 photoreceptor outer segment
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0005929 cilium
GO:0030991 intraciliary transport particle A
GO:0031514 motile cilium
GO:0032391 photoreceptor connecting cilium
GO:0097542 ciliary tip
GO:0097730 non-motile cilium

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8fgw, PDBe:8fgw, PDBj:8fgw
PDBsum8fgw
PubMed36775821
UniProtQ8NEZ3|WDR19_HUMAN WD repeat-containing protein 19 (Gene Name=WDR19)

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