Structure of PDB 8f5p Chain C Binding Site BS02

Receptor Information
>8f5p Chain C (length=1176) Species: 5689 (Leishmania tarentolae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MHTSVRWSETADAVKGIRPPVNSLCYSPSGDYVVASCGVRVLVYAASTGT
LLHSLMGHQDTIYCVDYSSDGKNFASGGADRTVIVWSSQGEGIVKYQHTE
AIQALAHNPTSSQLASVSSVDWGIWSPEQPKVSKYSLPSKGLCAAWTPNG
KTLAIGMLDGTVMMLSKTSEEKVIIRRPAPVWALAFTPLRENGIDVLAIG
SWDQRLSFYNLSGTAVGRERELDFDPCSVSYFNDGEYILLSGSDHKVTLF
TKDGNRLIELASADDWIWSARQRPRQKQFCYGTNDGTISCIDITISTVHT
IYDDQYVFRKDMTNLVVHQLLVDRKMVIPCNEYVQKIATFLDKLAVQLQE
RVIVFEFFYDDDRTMRYQDIAQIRRRLECSLLCVTTGAIIVSNDKRITMY
DFQGNKRREWSMESPVQLMKVVGGMEGREILLVGLNGGQVMKVFVDNPFP
TLLHKGTAPVKSAELSSSRSRLAVIDSTNTLQVLELGEKNELLFSEDNVT
AVAFNIDVDDNIAFTTGDNTLHIKTGSLPAYQQAVRGIVVGFKANHVFNL
HYSNMMVLDVPHAHALYKYVEMRDFDRAYEVACLGVADADWKMLGLHAMS
QLRLDIARKAFTHIQDTKLVELLKSLELRRRQKDSVLYGSILAFQGKYND
AARQFMKTGCELKAVEMYCDLKMWDNAKKICTDEKVLKDLIRQQARWAEE
SQNFVEAASLYESCGDYAKAIGMMGQAGQVEKLMKMCRSLPTSEVTLITE
CANFFRKHNAIPFAIEAYEKVQDHQALIGIYVAKGDWRNAFTILEKTPTL
AREVYVPWATWLADNDKFDEALEAFRAAKWPKEAMRLMETLATNSVTCRK
FRDAAFYYIHLAEEYGRFEETEKPTDVEKAARIRRSKECVRRADIYYAFS
GVYAHTTQPLPYNELSLFRTAKYLFGMCAESAIPINVGKGAILYTLSRIA
NRLEMVRTARAVFEKLQGVILPVSMMEQVDIETLLVRSKPVKDRDELLDR
CFRCNQLIAQLPMAGDRCPNCFHPCVRSFVNFECLPLVEFVLADELTDEE
AERIIVSGNDPFFTQLQYVLRPGRPTATYQPFVASADILKGFRRDEVFIV
RPRYGTLPVPNRYYRLMRSDVSVCLCNGCQHFFIAEDYEAECMRGSGCPL
CRYRPGKQVSRSMKQILFDMETAAAA
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain8f5p Chain C Residue 3001 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8f5p Mechanism of IFT-A polymerization into trains for ciliary transport.
Resolution3.4 Å
Binding residue
(original residue number in PDB)		C1232 C1235 C1254 C1257
Binding residue
(residue number reindexed from 1)		C1126 C1129 C1148 C1151
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Biological Process
GO:0035721 intraciliary retrograde transport
GO:0060271 cilium assembly
GO:0061512 protein localization to cilium
GO:1905515 non-motile cilium assembly
Cellular Component
GO:0030991 intraciliary transport particle A
GO:0097730 non-motile cilium

View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8f5p, PDBe:8f5p, PDBj:8f5p
PDBsum8f5p
PubMed36563665
UniProtA0A640KU89

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