Structure of PDB 8ewo Chain C Binding Site BS02

Receptor Information
>8ewo Chain C (length=259) Species: 208964 (Pseudomonas aeruginosa PAO1) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GMIQIDALPAFNDNYIWLLQDATSRRCAVVDPGDAKPVEAWLAAHPDWRL
SDILVTHHHHDHVGGVAALKELTGARVLGPANEKIPARDLALEDGERVEV
LGLVFEIFHVPGHTLGHIAYYHPAETPLLFCGDTLFAAGCGRLFEGTPAQ
MHHSLARLAALPANTRVYCTHEYTLSNLRFALAVEPDNAALRERFEEATR
LRERDRITLPSEISLELSTNPFLRVSENSVKKKADQRSGQQNRTPEEVFA
VLRAWKDQF
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain8ewo Chain C Residue 302 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB8ewo Crystal structure of putative glyoxylase II from Pseudomonas aeruginosa
Resolution2.47 Å
Binding residue
(original residue number in PDB)		D60 H61 D132 H170
Binding residue
(residue number reindexed from 1)		D61 H62 D133 H171
Annotation score1
Enzymatic activity
Enzyme Commision number 3.1.2.6: hydroxyacylglutathione hydrolase.
Gene Ontology
Molecular Function
GO:0004416 hydroxyacylglutathione hydrolase activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0019243 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:8ewo, PDBe:8ewo, PDBj:8ewo
PDBsum8ewo
PubMed
UniProtQ9I2T1|GLO2_PSEAE Hydroxyacylglutathione hydrolase (Gene Name=gloB)

[Back to BioLiP]