Structure of PDB 8e95 Chain C Binding Site BS02

Receptor Information
>8e95 Chain C (length=1095) Species: 1773 (Mycobacterium tuberculosis) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SSSNNSVPGAPNRVSFAKLREPLEVPGLLDVQTDSFEWLIGSPRWRESAA
ERGDVNPVGGLEEVLYELSPIEDFSGSMSLSFSDPRFDDVKAPVDECKDK
DMTYAAPLFVTAEFINNNTGEIKSQTVFMGDFPMMTEKGTFIINGTERVV
VSQLVRSPGVYFDETIDKSTDKTLHSVKVIPSRGAWLEFDVDKRDTVGVR
IDRKRRQPVTVLLKALGWTSEQIVERFGFSEIMRSTLEKDNTVGTDEALL
DIYRKLRPGEPPTKESAQTLLENLFFKEKRYDLARVGRYKVNKKLGLHVG
EPITSSTLTEEDVVATIEYLVRLHEGQTTMTVPGGVEVPVETDDIDHFGN
RRLRTVGELIQNQIRVGMSRMERVVRERMTTQDVEAITPQTLINIRPVVA
AIKEFFGTSQLSQFMDQNNPLSGLTHKRRLSALGPGGLSRERAGLEVRDV
HPSHYGRMCPIETPEGPNIGLIGSLSVYARVNPFGFIETPYRKVVDGVVS
DEIVYLTADEEDRHVVAQANSPIDADGRFVEPRVLVRRKAGEVEYVPSSE
VDYMDVSPRQMVSVATAMIPFLEHDDANRALMGANMQRQAVPLVRSEAPL
VGTGMELRAAIDAGDVVVAEESGVIEEVSADYITVMHDNGTRRTYRMRKF
ARSNHGTCANQCPIVDAGDRVEAGQVIADGPCTDDGEMALGKNLLVAIMP
WEGHNYEDAIILSNRLVEEDVLTSIHIEEHEIDARDTKLGAEEITRDIPN
ISDEVLADLDERGIVRIGAEVRDGDILVGKVTPKGREVRDTSLKVPHGES
GKVIGIRVFSREDEDELPAGVNELVRVYVAQKRKISDGDKLAGRHGNKGV
IGKILPVEDMPFLADGTPVDIILNTHGVPRRMNIGQILETHLGWCAHSGW
KVDAAKGVPDWAARLPDELLEAQPNAIVSTPVFDGAQEAELQGLLSCTLP
NRDGDVLVDADGKAMLFDGRSGEPFPYPVTVGYMYIMKLHHLVDDKIHAR
STGPYSMITQQPLGGKAQFGGQRFGEMECWAMQAYGAAYTLQELLTIKSD
DTVGRVKVYEAIVKGENIPEPGIPESFKVLLKELQSLCLNVEVLS
Ligand information
Receptor-Ligand Complex Structure
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PDB8e95 Structural and functional basis of the universal transcription factor NusG pro-pausing activity in Mycobacterium tuberculosis.
Resolution2.9 Å
Binding residue
(original residue number in PDB)		W211 D227 L463 R467
Binding residue
(residue number reindexed from 1)		W186 D202 L438 R442
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0005515 protein binding
GO:0016779 nucleotidyltransferase activity
GO:0032549 ribonucleoside binding
GO:0034062 5'-3' RNA polymerase activity
Biological Process
GO:0006351 DNA-templated transcription
GO:0046677 response to antibiotic
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0009274 peptidoglycan-based cell wall

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8e95, PDBe:8e95, PDBj:8e95
PDBsum8e95
PubMed37116494
UniProtP9WGY9|RPOB_MYCTU DNA-directed RNA polymerase subunit beta (Gene Name=rpoB)

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