Structure of PDB 8e2q Chain C Binding Site BS02

Receptor Information
>8e2q Chain C (length=153) Species: 562 (Escherichia coli) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VEFSHEYWMRHALALAKRARDEREVPVGAVLVLNNRVIGEGWNRGIGLHD
PTAHAEIMALRQGGLVMQNYRLYDATLYTTFEPCVMCAGAMIHSRIGRVV
FGVRNAKTGAAGSLMDVLHHPGMNHRVEITEGILADECEALLCRFFRMPR
RVF
Ligand information
Receptor-Ligand Complex Structure
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PDB8e2q Improved cytosine base editors generated from TadA variants.
Resolution2.34 Å
Binding residue
(original residue number in PDB)		R74 Y76 R98 N127
Binding residue
(residue number reindexed from 1)		R71 Y73 R95 N124
Enzymatic activity
Enzyme Commision number 3.5.4.33: tRNA(adenine(34)) deaminase.
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0008251 tRNA-specific adenosine deaminase activity
GO:0008270 zinc ion binding
GO:0016787 hydrolase activity
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
GO:0052717 tRNA-specific adenosine-34 deaminase activity
Biological Process
GO:0002100 tRNA wobble adenosine to inosine editing
GO:0006382 adenosine to inosine editing
GO:0008033 tRNA processing

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Molecular Function
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Biological Process
External links
PDB RCSB:8e2q, PDBe:8e2q, PDBj:8e2q
PDBsum8e2q
PubMed36624149
UniProtP68398|TADA_ECOLI tRNA-specific adenosine deaminase (Gene Name=tadA)

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