Structure of PDB 8dvv Chain C Binding Site BS02

Receptor Information
>8dvv Chain C (length=3886) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EIQFLRTDDEVVLQCTATIHKEQQKLCLAAEGFGNRLCFLESTSNSKNVP
PDLSICTFVLEQSLSVRALQEMLANMKTAQGGGHRTLLYGHAILLRHSYS
GMYLCCLSTSRSSTDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEKVR
VGDDLILVSVSSERYLHLSYGNSSWHVDAAFQQTLWSVAPISSGSEAAQG
YLIGGDVLRLLHGHMDECLTVPSGEHGEEQRRTVHYEGGAVSVHARSLWR
LETLRVAWSGSHIRWGQPFRLRHVTTGKYLSLMEDKNLLLMDKEKADVKS
TAFAFRSSKEKLRKEVDGMGTSEIKYGDSICYIQHVDTGLWLTYQAIQRK
AIMHHEGHMDDGLNLSRSQHEESRTARVIRSTVFLFNRFIRGLDALSKKV
IDLPIESVSLSLQDLIGYFHPPDEHLEHEDKQNRLRALKNRQNLFQEEGM
INLVLECIDRLHVYSSAAHFADVAGREAGESWKSILNSLYELLAALIRGN
RKNCAQFSGSLDWLISRLERLEASSGILEVLHCVLVESPEALNIIKEGHI
KSIISLLDKHGRNHKVLDVLCSLCVCHGVAVRSNQHLICDNLLPGRDLLL
QTRLVNHVSSMRPNIFLGVSEGSAQYKKWYYELMVDHTEPFVTAEATHLR
VGWASTEGYSPYNGVGDDLFSYGFDGLHLWSGCIARTVSSPNQHLLRTDD
VISCCLDLSAPSISFRINGQPVQGMFENFNIDGLFFPVVSFSAGIKVRFL
LGGRHGEFKFLPPPGYAACYEAVLPKEKLKVEHSREYKQERTYTRDLLGP
TLERIRERLAENIHELWVMNKIELGWQYGPVRDDNKRQHPCLVEFCKLPE
QERNYNLQMSLETLKTLLALGCHVGIADEHAEEKVKKMKLPKNYQLTSGY
KPAPMDLSFIKLTPSQEAMVDKLAENAHNVWARDRIRQGWTYGIQQDVKN
RRNPRLVPYTLLDDRTKKSNKDSLREAVRTLLGYGGERFRIFRAEKTYAV
KAGRWYFEFEAVTAGDMRVGWSRPGCQPDLELGSDDRAFAFDGFKAQRWH
QGNEHYGRSWQAGDVVGCMVDMNEHTMMFTLNGEILLDDSGSELAFKDFD
VGDGFIPVCSLGVAQVGRMNFGKDVSTLKYFTICGLQEGYEPFAVNTNRD
ITMWLSKRLPQFLQVPSNHEHIEVTRIDGTIDSSPCLKVTQKSFGSQNNN
TDIMFYRLSMPISTYYYSVRIFPGQEPANVWVGWITSDFHQYDTGFDLDR
VRTVTVTLGDEKGKVHESIKRSNCYMVCAGESMSPGQGRNNSNGLEIGCV
VDAASGLLTFIANGKELSTYYQVEPSTKLFPAVFAQATSPVLWSRMPNQF
LKVDVSRISERQGWLVQCLDPLQFMSLHIPEENRSVDILELTEQEELLQF
HYHTLRLYSAVCALGNHRVAHALCSHVDEPQLLYAIENKYMPGLLRAGYY
DLLIDIHLSSYATARLMMNNEFIVPMTEETKSITLFPDENKKHGLPGIGL
STSLRPRMRFSSPSFVSISNDCYQYSPEFPLDILKAKTIQMLTEAVKEGS
LHARDPVGGTTEFLFVPLIKLFYTLLIMGIFHNEDLKHILQLIEPGLLQM
KLPEPVKLQMCLLLQYLCDCQVRHRIEAIVAFSDDFVAKLQDNQRFRYNE
LLDFHEDLMTHCGIELDEDGSLDGSNDLTIRGRLLDLVEKVTYLKKCSSL
QQLISETMVRWAQESVIEDPELVRAMFVLLHRQYDGIGGLVRALPKTYTI
NGVSVEDTINLLASLGQIRSLLSGKEEEKLMIRGLGDIMNNKVFYQHPNL
MRALGMHETVMEVMVNVLGGGESKEITFPKMVANCCRFLCYFCRISRQNQ
KAMFDHLSYLLENSSVGLASPAMRGSTPLDVAAASVMDNNELALALREPD
LEKVVRYLAGCGLQSCQMLVSKGYPDIGWVEGERYLDFLRFAVFCNGESV
EENANVVVRLLIRRPECFGPALRGEGGNGLLAAMEEAIKIAEDPMGNAIM
TFYAALIDLLGRCAPEMHLIHAGKGEAIRIRSILRSLGDLVGVISIAFQM
PTIAKDGKVVEPDMSAGFCPDHKAAMVLFLDRVYGIEVQDFLLHLLEVGF
LPDLRAAASLSATDMALALNRYLCTAVLPLLQLRPSMMQHLLRRLVFDVP
LLNEHAKMPLKLLTNHYERCWKYYCLPGGWGNFGAASEEELHLSRKLFWG
IFDALSQKKYEQELFKLALPCLSAVAGALPPDYMESNYVSMMEKQSSMFN
PQPVDTSNITIPEKLEYFINKYAEHSHDKWSMDKLANGWIYGEIYSDSSK
IQPLMKPYKLLSEKEKEIYRWPIKESLKTMLAWGWRIERTREGDSMALYN
AAHGYSPRAIDMSNVTLSRDLHAMAEMMAENYHNIWAKKKKLELESKGGG
NHPLLVPYDTLTAKEKAKDREKAQDIFKFLQISGYVVSRCTGGHASNKEK
EMVTSLFCKLGVLVRHLGQTLDARTVMKTGLDSVKSALRAFLDNAAEDLE
KTMENLKQGQFTHTRSQPKGVTQIINYTTVALLPMLDKHNVYSIYNTRSS
RERAALSLPANVEDVCPNIPSLEKLMTEIIELAESGIRYTQMPYMMEVVL
PMLCSYMSRWWEHGPENHPERAEMCCTALNSEHMNTLKIIYNNLGIDEGF
SQPIINKVKPQLLKTHFLPLMEKLKKKAAMVVSEEDHLKAEARGDMSEAE
LLILDEFTTLARDLYAFYPLLIRFVDYNRAKWLKEPNPYWSKSHNFKREE
QNFVVQNEINNMSFLITDTKSKMSKAAISDQERKKMKRKGDRYSMQTSLI
VAALKRLLPIGLNICAPGDQELIALAKNRFSLKDTEEEVRDIIRSNIHLQ
GKLELGIANVLFHLEQKSKYPRHRAVNLFLQGYEKSWIETEEHYFEDKLI
EDLAKPGAELPEEAMKRVDPLHQLILLFSRTALTEKCKLEEDFLYMAYAD
IMAKSCHDEEEVKSFEEKEMEKQKLLYQQARLHDRGAAEMVLQTISASKG
ETGPMVAATLKLGIAILNGGNSTVQQKMLDYLKEKKDVGFFQSLAGLMQS
CSVLDLNAFERQNKAEGLGMVTEEGSGEKVLQDDEFTCDLFRFLQLLCEG
HNSDFQNYLRTQTGNNTTVNIIISTVDYLLRVQESISDFYWYYSGKDIID
EQGQRNFSKAIQVAKQVFNTLTEYIQGPCTGNQQSLAHSRLWDAVVGFLH
VFAHMQMKLSQDSSQIELLKELMDLQKDMVVMLLSMLEGNVVNGTIGKQM
VDMLVESSNNVEMILKFFDMFLKLKDLTSSDTFKEYDPDGKGVISKRDFH
KAMESHKHYTQSETEFLLSCAETDENETLDYEEFVKRFHEPAKDIGFNVA
VLLTNLSEHMPNDTRLQTFLELAESVLNYFQPFLGRIEIMGSAKRIERVY
FEISESSRTQWEKPQVKESKRQFIFDVVNEGGEKEKMELFVNFCEDTIFE
MQLAAQIIAYQQKLLNYFARNFYNMRMLALFVAFAINFILLFYKVSVHYV
LEESSGYMEPTLRILAILHTIISFFCIIGYYCLKVPLVIFKREKEVARKL
EFDGLYITEQPSEDDIKGQWDRLVINTQSFPNNYWDKFVKRKVMDKYGEF
YGRDRISELLGMDSAVLNSIDVKYQMWKLGVVFTDNSFLYLAWYMTMSVL
GHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLY
TVVAFNFFRKFYNKSEDGDTPDMKCDDMLTCYMFHMYVGVRAGGGIGDEI
EDPAGDEYEIYRIIFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVK
EDMETKCFICGIGNDYFDTVPHGFETHTLQEHNLANYLFFLMYLINKDET
EHTGQESYVWKMYQERCWEFFPAGDCFRKQYEDQLN
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain8dvv Chain C Residue 5002 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8dvv Recombinant mouse RyR2 triple phosphomimetic mutant S2807D/S2813D/S2030D in complex with FKBP12.6 and nanodisc under open-state conditions
Resolution3.68 Å
Binding residue
(original residue number in PDB)		C4890 H4907 H4912
Binding residue
(residue number reindexed from 1)		C3810 H3827 H3832
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
GO:0005219 ryanodine-sensitive calcium-release channel activity
GO:0005262 calcium channel activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0015278 intracellularly gated calcium channel activity
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0034236 protein kinase A catalytic subunit binding
GO:0034237 protein kinase A regulatory subunit binding
GO:0042802 identical protein binding
GO:0043924 suramin binding
GO:0048763 calcium-induced calcium release activity
GO:0097159 organic cyclic compound binding
Biological Process
GO:0001666 response to hypoxia
GO:0002027 regulation of heart rate
GO:0003143 embryonic heart tube morphogenesis
GO:0003220 left ventricular cardiac muscle tissue morphogenesis
GO:0003300 cardiac muscle hypertrophy
GO:0005513 detection of calcium ion
GO:0006811 monoatomic ion transport
GO:0006816 calcium ion transport
GO:0006874 intracellular calcium ion homeostasis
GO:0010460 positive regulation of heart rate
GO:0010881 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
GO:0010882 regulation of cardiac muscle contraction by calcium ion signaling
GO:0014808 release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
GO:0014850 response to muscle activity
GO:0019722 calcium-mediated signaling
GO:0031000 response to caffeine
GO:0035994 response to muscle stretch
GO:0051209 release of sequestered calcium ion into cytosol
GO:0051284 positive regulation of sequestering of calcium ion
GO:0051649 establishment of localization in cell
GO:0051775 response to redox state
GO:0055085 transmembrane transport
GO:0055117 regulation of cardiac muscle contraction
GO:0060048 cardiac muscle contraction
GO:0060402 calcium ion transport into cytosol
GO:0070588 calcium ion transmembrane transport
GO:0071313 cellular response to caffeine
GO:0071872 cellular response to epinephrine stimulus
GO:0072599 establishment of protein localization to endoplasmic reticulum
GO:0086005 ventricular cardiac muscle cell action potential
GO:0086029 Purkinje myocyte to ventricular cardiac muscle cell signaling
GO:0097050 type B pancreatic cell apoptotic process
GO:0097553 calcium ion transmembrane import into cytosol
GO:0098735 positive regulation of the force of heart contraction
GO:0098904 regulation of AV node cell action potential
GO:0098907 regulation of SA node cell action potential
GO:0098910 regulation of atrial cardiac muscle cell action potential
GO:0098911 regulation of ventricular cardiac muscle cell action potential
Cellular Component
GO:0005790 smooth endoplasmic reticulum
GO:0016020 membrane
GO:0016529 sarcoplasmic reticulum
GO:0030017 sarcomere
GO:0030018 Z disc
GO:0032991 protein-containing complex
GO:0033017 sarcoplasmic reticulum membrane
GO:0034704 calcium channel complex

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8dvv, PDBe:8dvv, PDBj:8dvv
PDBsum8dvv
PubMed
UniProtE9Q401|RYR2_MOUSE Ryanodine receptor 2 (Gene Name=Ryr2)

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