Structure of PDB 8cxu Chain C Binding Site BS02

Receptor Information
>8cxu Chain C (length=540) Species: 272563 (Clostridioides difficile 630) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GIYYTPKIIVDYIVKKTLKNHDIIKNPYPRILDISCGCGNFLLEVYDILY
DLFEENIYELKKKYDENYWTVDNIHRHILNYCIYGADIDEKAISILKDSL
TNKIKINLFCCDSLKKKWRYKFDYIVGNPPYIGHKKLEKKYKKFLLEKYS
EVYKDKADLYFCFYKKIIDILKQGGIGSVITPRYFLESLSGKDLREYIKS
NVNVQEIVDFLGANIFKNIGVSSCILTFDKKKTKETYIDVFKIKNEDICI
NKFETLEELLKSSKFEHFNINQRLLSDEWILVNKDDETFYNKIQEKCKYS
LEDIAISFQGIITGCDKAFILSKDDVKLNLVDDKFLKCWIKSKNINKYIV
DKSEYRLIYSNDIDNENTNKRILDEIIGLYKTKLENRRECKSGIRKWYEL
QWGREKLFFERKKIMYPYKSNENRFAIDYDNNFSSADVYSFFIKEEYLDK
FSYEYLVGILNSSVYDKYFKITAKKMSKNIYDYYPNKVMKIRIFRDNNYE
EIENLSKQIISILLNKSIDKGKVEKLQIKMDNLIMDSLGI
Ligand information
Receptor-Ligand Complex Structure
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PDB8cxu Systematic Design of Adenosine Analogs as Inhibitors of a Clostridioides difficile- Specific DNA Adenine Methyltransferase Required for Normal Sporulation and Persistence.
Resolution2.28 Å
Binding residue
(original residue number in PDB)		H171 K172 K179 D192 K193 I349 D353 K378 S379 K380 R425 Q438 W439 Y455 K456 A473
Binding residue
(residue number reindexed from 1)		H134 K135 K142 D155 K156 I312 D316 K341 S342 K343 R388 Q401 W402 Y418 K419 A436
Enzymatic activity
Enzyme Commision number 2.1.1.72: site-specific DNA-methyltransferase (adenine-specific).
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0008168 methyltransferase activity
GO:0009007 site-specific DNA-methyltransferase (adenine-specific) activity
Biological Process
GO:0006304 DNA modification
GO:0032259 methylation

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Molecular Function
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Biological Process
External links
PDB RCSB:8cxu, PDBe:8cxu, PDBj:8cxu
PDBsum8cxu
PubMed36581322
UniProtQ183J3

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