Structure of PDB 8cqx Chain C Binding Site BS02

Receptor Information

>8cqx Chain C (length=300) Species: 275 (Thermus sp.)

MILVVGSLNMDLVLRVKRLPRPGETVLGEDYQTHPGGKGANQAVAIARLG
GKVRMLGRVGEDPFGQALKSGLAQEGVDVAWVLETPGPSGTGFILVDPEG
QNQIAVAPGANARLVPEDLPATAFQGVGVVLLQLEIPLETVVRAAALGRK
AGARILLNAAPAHALPSEILQSVDLLLVNEVEAAQLTEASPPRTPEEALA
LARQLRGRAPQAQVVLTLGAQGAVWSGTEESHFPAFPVRAVDTTAAGDAF
AGALALGLAEGQNMRAALRFANAAGALATTRPGAQPSLPFRDEVEALLFG

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 8cqx Chain C Residue 402

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8cqx Ribokinase from T.sp mutant A92G
• Resolution: 2.27 Å
• Binding residue (original residue number in PDB): D242 T244 A278 R281 G283 S287
• Binding residue (residue number reindexed from 1): D242 T244 A278 R281 G283 S287
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 2.7.1.15: ribokinase.

Gene Ontology

Molecular Function

• GO:0004747 ribokinase activity
• GO:0005524 ATP binding
• GO:0016301 kinase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006014 D-ribose metabolic process
• GO:0016310 phosphorylation
• GO:0019303 D-ribose catabolic process
• GO:0046835 carbohydrate phosphorylation

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol

External links

• PDB: RCSB:8cqx, PDBe:8cqx, PDBj:8cqx
• PDBsum: 8cqx
• UniProt: A0A0B0SD75