Structure of PDB 8ch6 Chain C Binding Site BS02

Receptor Information
>8ch6 Chain C (length=815) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EEQKERKIMKLLLKIKNGTPPMRKAALRQITDKAREFGAGPLFNQILPLL
MSPTLEDQERHLLVKVIDRILYKLDDLVRPYVHKILVVIEPLLIDEDYYA
RVEGREIISNLAKAAGLATMISTMRPDIDNMDEYVRNTTARAFAVVASAL
GIPSLLPFLKAVCKSKKSWQARHTGIKIVQQIAILMGCAILPHLRSLVEI
IEHGLVDEQQKVRTISALAIAALAEAATPYGIESFDSVLKPLWKGIRQHR
GKGLAAFLKAIGYLIPLMDAEYANYYTREVMLILIREFQSPDEEMKKIVL
KVVKQCCGTDGVEANYIKTEILPPFFKHFWQHRMALDRRNYRQLVDTTVE
LANKVGAAEIISRIVDDLKDEAEQYRKMVMETIEKIMGNLGAADIDHKLE
EQLIDGILYAFQEQTTEDSVMLNGFGTVVNALGKRVKPYLPQICGTVLWR
LNNKSAKVRQQAADLISRTAVVMKTCQEEKLMGHLGVVLYEYLGEEYPEV
LGSILGALKAIVNVIGMHKMTPPIKDLLPRLTPILKNRHEKVQENCIDLV
GRIADRGAEYVSAREWMRICFELLELLKAHKKAIRRATVNTFGYIAKAIG
PHDVLATLLNNLKVQERQNRVCTTVAIAIVAETCSPFTVLPALMNEYRVP
ELNVQNGVLKSLSFLFEYIGEMGKDYIYAVTPLLEDALMDRDLVHRQTAS
AVVQHMSLGVYGFGCEDSLNHLLNYVWPNVFETSPHVIQAVMGALEGLRV
AIGPCRMLQYCLQGLFHPARKVRDVYWKIYNSIYIGSQDALIAHYPRIYN
DDKNTYIRYELDYIL
Ligand information
>8ch6 Chain g (length=76) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ucggccuccgaacgguaagagccuagcauguagaacugguuaugauguca
uacuuauccugucccuuuuuuuucca
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Receptor-Ligand Complex Structure
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PDB8ch6 Structural basis of catalytic activation in human splicing.
Resolution5.9 Å
Binding residue
(original residue number in PDB)		H1069 R1075 R1109 V1110 N1142 V1183 H1225
Binding residue
(residue number reindexed from 1)		H580 R586 R620 V621 N653 V694 H736
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003729 mRNA binding
GO:0005515 protein binding
GO:1990935 splicing factor binding
Biological Process
GO:0000245 spliceosomal complex assembly
GO:0000375 RNA splicing, via transesterification reactions
GO:0000398 mRNA splicing, via spliceosome
GO:0006338 chromatin remodeling
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:0045943 positive regulation of transcription by RNA polymerase I
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0045945 positive regulation of transcription by RNA polymerase III
GO:1903241 U2-type prespliceosome assembly
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005681 spliceosomal complex
GO:0005684 U2-type spliceosomal complex
GO:0005686 U2 snRNP
GO:0005689 U12-type spliceosomal complex
GO:0005730 nucleolus
GO:0016607 nuclear speck
GO:0034693 U11/U12 snRNP
GO:0071004 U2-type prespliceosome
GO:0071005 U2-type precatalytic spliceosome
GO:0071013 catalytic step 2 spliceosome
GO:0110016 B-WICH complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8ch6, PDBe:8ch6, PDBj:8ch6
PDBsum8ch6
PubMed37165190
UniProtO75533|SF3B1_HUMAN Splicing factor 3B subunit 1 (Gene Name=SF3B1)

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