Structure of PDB 8c60 Chain C Binding Site BS02

Receptor Information
>8c60 Chain C (length=213) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SGGLMEQIQALLAPPKTDDSCDSCKEGGDLLCCDHCPAAFHLQCCNPPLS
EEMLPPGEWMCHRCTVRRKKREQKPQLRRPFELLIAAAMERNPTQFQLPN
ELTCTTQHELDHNGLVPLPVKVCFTCNRSCRVAPLIQCDYCPLLFHMDCL
EPPLTAMPLGRWMCPNHIEHVVLNQKNMTLSNRCQVFDRFQDTVSQHVVK
VDFLNRIHKKHPP
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain8c60 Chain C Residue 1102 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8c60 Mechanism of assembly, activation and lysine selection by the SIN3B histone deacetylase complex.
Resolution3.4 Å
Binding residue
(original residue number in PDB)		C274 C277 H297 C300
Binding residue
(residue number reindexed from 1)		C123 C126 H146 C149
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0001222 transcription corepressor binding
GO:0003714 transcription corepressor activity
GO:0005515 protein binding
GO:0035091 phosphatidylinositol binding
GO:0046872 metal ion binding
Biological Process
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0045892 negative regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0017053 transcription repressor complex
GO:0070822 Sin3-type complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8c60, PDBe:8c60, PDBj:8c60
PDBsum8c60
PubMed37137925
UniProtQ96QT6|PHF12_HUMAN PHD finger protein 12 (Gene Name=PHF12)

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