Structure of PDB 8a3w Chain C Binding Site BS02

Receptor Information
>8a3w Chain C (length=325) Species: 347515 (Leishmania major strain Friedlin) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RPSVSVYSASSDSVVGTCPLPAVFTAPIRSDIVKFVHTNMAKNSRQAYAV
NRLSGMNHSAHSWGTGRAVARIPRISGGGTSTSGAGAFGNMCRGGRMFAP
TKIFRRWHRKINLHQKRFAVVSALAASSVPSLVMSRGHQIGNVPEVPLVV
EDSIQGYEKTKEAMAFLKAIAAIDDVNRVNDSREIRAGRGKMRNRRYVAR
RGPMLVMPNNKGTRAFRNIFGLDLANVSALNLLHLAPGGHVGRFVIWTQS
AFEQLDKIFGTFTEASAVKKGFTLPAPMLTNTDVTRIMQSEEVRRVLKPK
KLQTPTNGMKNRRLRLRLNPYVKRE
Ligand information
>8a3w Chain 1 (length=1467) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
agaccugaguguggcaggacuacccgccgaacuuaagcauauuacucagc
ggaggaaaagaaaacaaccgugauucucucagugagcggcgagcgaagag
ggaacgaacucguugccgaaucgggucuuacaaggccuugaguuguggca
cgugguuggugcaggaguggcgaaauucaagaaagcaaacccguugcuga
auacaaucauggaguauugagccaaagaagguguuagcccauugagccau
aaaccugagcgccucaugaacuaagcgaguagcacuguuugggaaugcag
ugucaaguuggcagguauuugucugccaaaguuaaauacagaguaggaag
accgauagcgaacaaguagcgugagcgaaaguuugaaaagcacuuuggaa
agagagugaaauagaaccugaagucgugacaaagacaauggaaguaccuc
cauuucaacggccagaaccagcccuugcauuauccugugggaaauccggc
ggggugcaaugguguuggcgauggaaauggggugcccccacccgucuuga
aacacggaccaaggagucaaacagacgcgcaagggaggagauaugccagu
acuucucucguacugaaagggagaugcaaugcaucuguggugugcacacg
ucaaauccguuugauuugcccaacaccgaccggcccuccguggguugcgu
uggagugugccuguuuggacccgaaagguggugaacuaugccugaacaag
gugaagcccggggaaacccagguggaggccuguagcgaugcugacgugca
aaucgcucguaugauuuggguaucggagcgaaagacucaucgaaccaccu
aguagcugguucacaucgaaguuucccucaggauagcuggugcuaguaga
aguauugugcgguaaagcacuuuaaaugugcaaacaaaccggccuuagcc
aacugcaaggccggaaagaaaagaauuagaggcaccaagugggccuucuu
cgguaagcggagcaggcgaugcggaaugaaccgcuuagggauauguggcg
ucaaaacuuaugggcucauucucgauacgugaaaaggguguuggugcacc
ggccccgaaaauggaugacgcuuaagcccaauuagugauugcccauuauu
ccuuugguaagggcgagaaaguguagcccuuccgauguagauguggccug
gagguuaggacgaagcuuauggcgugagccuaagauggaccggccucuag
ugcagaucuugguuggcguagcaaagaucuaacggagauauacucaacau
gcaacguuggauacuggagcggggaaggauuucgugccaacggcacucgu
acacgaguuguucggaaacugagcacaacguuauaucguuuuguuaggaa
agugaaggaacugaaaaggggcaacagagaaccugggauuauauuccaaa
aagaaauugcauguggg
......................<<<<<......<......>.......>>
>>.>.........<<....>>..<<<<<<......<<.....>>....>>
>>>>...<<<...<<<<<..<<<<<<<......>>>>>.>>....>>>>>
.<<<...<<<<<<<<.<<<<<......<<<...<<<<.......>>>>..
...<<....>>.....>>>.<<.......((.....>>)).....>>>>>
...>>>..>>>>>.>>>..............<<<<<<<........>>>>
>>>......<<<<<........>>>>>..>>>..................
..................<<....>>................<<<<....
>>>>..................................<<<..<<<<<<.
<<<<<......<<<<.<<<<.....<<<<<...<<<<<<<....>>..>>
>>>>>>>>.>>>>.>>>>......>>>>>>>>>>>..>>>.<<<<.....
...>>>><<<<<<....<<<<<<<.<<<<<..<<<<..<<.<........
>>>..>>>>...<<....>>..<<<<<...>>>>>...<<<<<...<<.<
<<<<<....>>>>>>.>>....>>>>><<<<<<<<<.....>>>>>>.>>
>...>>>>>.>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<
<....<<<.<<<....>>>.>>>.....>>>...<<<<.<<.<<......
..>>>>>>>>....>>>>>>>>>...<<.......>>......>>>>>>.
..>..>.>>...<<<<<....<.<<<....>>>.><<<<<<<<<.....<
<...<<<<<<....<<<..>>.>....>>>>>>.....<<<<<<<<.<<.
....>>>>>>>>>>...........>>...>>>>>>>.>>..<<<<.<<<
<<.....>>>>>.>>>>...<<<<......>>>>..<<<<<<<...<<<(
((......<..<<<<........<...........<<<<....<..>...
.>>>>...........))).>....>>>>.>.........>>>...>>>>
>>><<<<.<<<<<.............>>>>>>>>>....>>>>>..<.<<
<<<<<<........<<<<..<<<....>>>.>>>.>.....>>>>>>>>.
.>.....>>>>>>..............<<<<<<<................
....>>>>>>>....................<<<<<....<<.....>>.
.>>>>>....<<..........<<.<<<<<......>>>>..........
......<....>......>.>>..........<<<<.........>>...
.>>.>>...........
Receptor-Ligand Complex Structure
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PDB8a3w CRYO-EM STRUCTURE OF LEISHMANIA MAJOR 80S RIBOSOME : WILD TYPE
Resolution2.89 Å
Binding residue
(original residue number in PDB)
R32 K37 F38 T41 M43 N46 R48 Q49 Y51 R55 L56 S57 M59 H61 S62 T68 V72 A73 R74 P76 G82 T83 T85 A88 N93 M94 R96 R99 F101 F107 R108 R109 K113 N115 H117 Q118 R120 R139 K162 T163 R181 E187 R189 A190 G191 R192 R196 R198 Y200 R203 R204 R217 N221 A232 N234 G241 H243 K273 K304 L305 T317 N318 N322
Binding residue
(residue number reindexed from 1)
R29 K34 F35 T38 M40 N43 R45 Q46 Y48 R52 L53 S54 M56 H58 S59 T65 V69 A70 R71 P73 G79 T80 T82 A85 N90 M91 R93 R96 F98 F104 R105 R106 K110 N112 H114 Q115 R117 R136 K159 T160 R178 E184 R186 A187 G188 R189 R193 R195 Y197 R200 R201 R214 N218 A229 N231 G238 H240 K270 K301 L302 T306 N307 N311
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
Biological Process
GO:0006412 translation
Cellular Component
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component
External links
PDB RCSB:8a3w, PDBe:8a3w, PDBj:8a3w
PDBsum8a3w
PubMed
UniProtE9ADW5

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