Structure of PDB 7ywx Chain C Binding Site BS02

Receptor Information
>7ywx Chain C (length=98) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AKSRSSRAGLQFPVGRVHRLLRKGNYAERVGAGAPVYLAAVLEYLTAEIL
ELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGRVTIAQGGVLPNI
Ligand information
>7ywx Chain J (length=162) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ccgctttgaggccttcgttggaaacgggaatatgttcacataaaaactag
acagaagcattctcagaaacttctatgtgatgtttgcattcaactcatag
agttgaacattccttttcatagagcagttttgaaacactctttttgtagt
atctggaattgg
Receptor-Ligand Complex Structure
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PDB7ywx Structure of the human inner kinetochore bound to a centromeric CENP-A nucleosome.
Resolution12.0 Å
Binding residue
(original residue number in PDB)		R29 R42 V43 A45 T76 R77
Binding residue
(residue number reindexed from 1)		R16 R29 V30 A32 T63 R64
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003674 molecular_function
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0030527 structural constituent of chromatin
GO:0031492 nucleosomal DNA binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0008285 negative regulation of cell population proliferation
GO:0031507 heterochromatin formation
Cellular Component
GO:0000786 nucleosome
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7ywx, PDBe:7ywx, PDBj:7ywx
PDBsum7ywx
PubMed35420891
UniProtQ93077|H2A1C_HUMAN Histone H2A type 1-C (Gene Name=H2AC6)

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