Structure of PDB 7xam Chain C Binding Site BS02

Receptor Information

>7xam Chain C (length=275) Species: 246196 (Mycolicibacterium smegmatis MC2 155)

GIRKYKPTTPGRRGASVSDFAEITRSTPEKSLVRPLHGKGGRNAHGRITT
RHKGGGHKRAYRVIDFRRHDKDGVNAKVAHIEYDPNRTANIALLHYLDGE
KRYIIAPQGLKQGDVIESGANADIKPGNNLPLRNIPAGTVIHAVELRPGG
GAKLARSAGVSIQLLGKEGTYAALRMPSGEIRRVDVRCRATVGEVGNAEQ
SNINWGKAGRMRWKGKRPTVRGVVMNPVDHPHGGGEGKTSGGRHPVSPWG
KPEGRTRKPNKPSDKLIVRRRRTGK

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 7xam Chain C Residue 303

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7xam Cryo-EM structures reveal a unique conformational dynamics of the Mycobacterium 23S rRNA helices
• Resolution: 3.5 Å
• Binding residue (original residue number in PDB): D85 R88
• Binding residue (residue number reindexed from 1): D84 R87
• Annotation score: 4

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0016740 transferase activity
• GO:0019843 rRNA binding

Biological Process

• GO:0002181 cytoplasmic translation
• GO:0006412 translation

Cellular Component

• GO:0005840 ribosome
• GO:0015934 large ribosomal subunit
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:7xam, PDBe:7xam, PDBj:7xam
• PDBsum: 7xam
• PubMed: 37709237
• UniProt: A0QSD4|RL2_MYCS2 Large ribosomal subunit protein uL2 (Gene Name=rplB)