Structure of PDB 7x75 Chain C Binding Site BS02

Receptor Information
>7x75 Chain C (length=1116) Species: 100226 (Streptomyces coelicolor A3(2)) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ASTAPLRISFAKIKEPLEVPNLLALQTESFDWLLGNDAWKARVESALESG
QDVPTKSGLEEIFEEISPIEDFSGSMSLTFRDHRFEPPKNSIDECKDRDF
TYAAPLFVTAEFTNNETGEIKSQTVFMGDFPLMTNKGTFVINGTERVVVS
QLVRSPGVYFDSSIDKTSDKDIFSAKIIPSRGAWLEMEIDKRDMVGVRID
RKRKQSVTVLLKALGWTTEQILEEFGEYESMRATLEKDHTQGQDDALLDI
YRKLRPGEPPTREAAQTLLENLYFNPKRYDLAKVGRYKVNKKLGADEPLD
AGVLTTDDVIATIKYLVKLHAGETETVGESGREIVVETDDIDHFGNRRIR
NVGELIQNQVRTGLARMERVVRERMTTQDVEAITPQTLINIRPVVASIKE
FFGTSQLSQFMDQNNPLSGLTHKRRLNALGPGGLSRERAGFEVRDVHPSH
YGRMCPIETPEGPNIGLIGSLASYGRINPFGFIETPYRKVVEGQVTDDVD
YLTADEEDRFVIAQANAALGDDMRFAEARVLVRRRGGEVDYVPGDDVDYM
DVSPRQMVSVATAMIPFLEHDDANRALMGANMMRQAVPLIKSESPLVGTG
MEYRSAADAGDVVKAEKAGVVQEVSADYITTTNDDGTYITYRLAKFSRSN
QGTSVNQKVIVAEGDRIIEGQVLADGPATENGEMALGKNLLVAFMPWEGH
NYEDAIILSQRLVQDDVLSSIHIEEHEVDARDTKLGPEEITRDIPNVSEE
VLADLDERGIIRIGAEVVAGDILVGKVTPKGETELTPEERLLRAIFGEKA
REVRDTSLKVPHGEIGKVIGVRVFDREEGDELPPGVNQLVRVYVAQKRKI
TDGDKLAGRHGNKGVISKINPIEDMPFLEDGTPVDIILNPLAVPSRMNPG
QVLEIHLGWLASRGWDVSGLAEEWAQRLQVIGADKVEPGTNVATPVFDGA
REDELAGLLQHTIPNRDGERMVLPSGKARLFDGRSGEPFPEPISVGYMYI
LKLHHLVDDKLHARSTGPYSMITQQPLGGKAQFGGQRFGEMEVWALEAYG
AAYALQELLTIKSDDVTGRVKVYEAIVKGENIPEPGIPESFKVLIKEMQS
LCLNVEVLSSDGMSIE
Ligand information
>7x75 Chain P (length=84) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ggcgacccggcgcccgctacggagtcaactacgggtagggggtatcgggc
aacgcggcactgaacaccgttgtcatgtgccttg
Receptor-Ligand Complex Structure
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PDB7x75 Structural basis of Streptomyces transcription activation by zinc uptake regulator.
Resolution3.45 Å
Binding residue
(original residue number in PDB)		N157 R161 R381 R407 P408 E415 T419 S420 Q424 F425 H1027 K1045 Q1051 R1052 M1056
Binding residue
(residue number reindexed from 1)		N142 R146 R366 R392 P393 E400 T404 S405 Q409 F410 H1012 K1030 Q1036 R1037 M1041
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0032549 ribonucleoside binding
GO:0034062 5'-3' RNA polymerase activity
Biological Process
GO:0006351 DNA-templated transcription
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7x75, PDBe:7x75, PDBj:7x75
PDBsum7x75
PubMed35871291
UniProtQ9L0L0|RPOB_STRCO DNA-directed RNA polymerase subunit beta (Gene Name=rpoB)

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