Structure of PDB 7w6l Chain C Binding Site BS02
Receptor Information
>7w6l Chain C (length=158) Species:
9606
(Homo sapiens) [
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PLGSKSSQYRKMKTEWKSNVYLARSRIQGLGLYAARDIEKHTMVIEYIGT
IIRNEVANRKEKLYESQNRGVYMFRMDNDHVIDATLTGGPARYINHSCAP
NCVAEVVTFERGHKIIISSSRRIQKGEELCYDYKFDFEDDQHKIPCHCGA
VNCRKWMN
Ligand information
>7w6l Chain M (length=7) Species:
9606
(Homo sapiens) [
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ARTKQTA
Receptor-Ligand Complex Structure
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PDB
7w6l
Structural basis for product specificities of MLL family methyltransferases.
Resolution
2.26 Å
Binding residue
(original residue number in PDB)
N4811 E4814 V4824 M4826 F4827 R4828 A4857 E4858 Y4886 K4887 F4888 E4891 I4897
Binding residue
(residue number reindexed from 1)
N58 E61 V71 M73 F74 R75 A104 E105 Y133 K134 F135 E138 I144
Enzymatic activity
Enzyme Commision number
2.1.1.364
: [histone H3]-lysine(4) N-methyltransferase.
External links
PDB
RCSB:7w6l
,
PDBe:7w6l
,
PDBj:7w6l
PDBsum
7w6l
PubMed
36108631
UniProt
Q8NEZ4
|KMT2C_HUMAN Histone-lysine N-methyltransferase 2C (Gene Name=KMT2C)
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