Structure of PDB 7w6j Chain C Binding Site BS02
Receptor Information
>7w6j Chain C (length=158) Species:
9606
(Homo sapiens) [
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DLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGIV
IRSILTDKREKYYDSKGIGSSYMFRIDDSEVVDATMHGNAARFINHSCEP
NCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDASNKLPCNCGA
KKCRKFLN
Ligand information
>7w6j Chain B (length=8) Species:
9606
(Homo sapiens) [
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ARTKQTAR
Receptor-Ligand Complex Structure
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PDB
7w6j
Structural basis for product specificities of MLL family methyltransferases.
Resolution
2.68 Å
Binding residue
(original residue number in PDB)
Y3858 S3883 M3885 F3886 R3887 Y3943 Y3945 K3946 F3947 E3950
Binding residue
(residue number reindexed from 1)
Y46 S71 M73 F74 R75 Y131 Y133 K134 F135 E138
Enzymatic activity
Enzyme Commision number
2.1.1.-
2.1.1.364
: [histone H3]-lysine(4) N-methyltransferase.
External links
PDB
RCSB:7w6j
,
PDBe:7w6j
,
PDBj:7w6j
PDBsum
7w6j
PubMed
36108631
UniProt
Q03164
|KMT2A_HUMAN Histone-lysine N-methyltransferase 2A (Gene Name=KMT2A)
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