Structure of PDB 7w6i Chain C Binding Site BS02
Receptor Information
>7w6i Chain C (length=159) Species:
9606
(Homo sapiens) [
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SDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGI
VIRSILTDKREKYYDSKGIGSSYMFRIDDSEVVDATMHGNAARFINHSCE
PNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDASNKLPCNCG
AKKCRKFLN
Ligand information
>7w6i Chain B (length=8) Species:
9606
(Homo sapiens) [
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ARTKQTAR
Receptor-Ligand Complex Structure
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PDB
7w6i
Structural basis for product specificities of MLL family methyltransferases.
Resolution
2.56 Å
Binding residue
(original residue number in PDB)
Y3858 D3869 E3872 S3883 M3885 F3886 R3887 Y3945 K3946 F3947 E3950
Binding residue
(residue number reindexed from 1)
Y47 D58 E61 S72 M74 F75 R76 Y134 K135 F136 E139
Enzymatic activity
Enzyme Commision number
2.1.1.-
2.1.1.364
: [histone H3]-lysine(4) N-methyltransferase.
External links
PDB
RCSB:7w6i
,
PDBe:7w6i
,
PDBj:7w6i
PDBsum
7w6i
PubMed
36108631
UniProt
Q03164
|KMT2A_HUMAN Histone-lysine N-methyltransferase 2A (Gene Name=KMT2A)
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