Structure of PDB 7uxw Chain C Binding Site BS02
Receptor Information
>7uxw Chain C (length=345) Species:
10090
(Mus musculus) [
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KLKKVLDKLRLKRKDISEAAETVNKVVERLLRRMQKRESEFKGVEQLNTG
SYYEHVKISAPNQFNVMFKLEVPRIELQEYYETGAFYLVKFNPLSHFLGV
LSATKMLSKFRKIIKEEVKEIKDIDVSVEKEKPGSPAVTLLIRNPEEISV
DIILALESKGSWPISTKEGLPIQGWLGTKVRTNLRREPFYLVPKNAQGET
WRLSFSHTEKYILNNHGIEKTCCESSGAKCCRKECLKLMKYLLEQLKKEF
QELDAFCSYHVKTAIFHMWTQDPQDSQWDPRNLSSCFDKLLAFFLECLRT
EKLDHYFIPKFNLFSQELIDRKSKEFLSKKIEYERNNGFPIFDKL
Ligand information
>7uxw Chain I (length=18) [
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atctgtacatgtacagat
Receptor-Ligand Complex Structure
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PDB
7uxw
ATP and GTP bind to Cyclic GMP AMP synthase (cGAS) through Mg coordination
Resolution
2.57 Å
Binding residue
(original residue number in PDB)
R158 L159 K160 R161 H203 K395
Binding residue
(residue number reindexed from 1)
R10 L11 K12 R13 H55 K233
Enzymatic activity
Enzyme Commision number
2.7.7.86
: cyclic GMP-AMP synthase.
External links
PDB
RCSB:7uxw
,
PDBe:7uxw
,
PDBj:7uxw
PDBsum
7uxw
PubMed
UniProt
Q8C6L5
|CGAS_MOUSE Cyclic GMP-AMP synthase (Gene Name=Cgas)
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