Structure of PDB 7uwh Chain C Binding Site BS02

Receptor Information
>7uwh Chain C (length=190) Species: 562 (Escherichia coli) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TQLVAGVDAVGRGPLVGAVVTAAVILDPARPIAGLNDSKKLSEKRRLALY
EEIKEKALSWSLGRAEPHEIDELNILHATMLAMQRAVAGLHIAPEYVLID
GNRCPKLPMPAMAVVKGDSRVPEISAASILAKVTRDAEMAALDIVFPQYG
FAQHKGYPTAFHLEKLAEHGATEHHRRSFGPVKRALGLAS
Ligand information
Receptor-Ligand Complex Structure
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PDB7uwh RNA polymerase drives ribonucleotide excision DNA repair in E. coli.
Resolution3.1 Å
Binding residue
(original residue number in PDB)		D16 A17 V18 G19 R20 D108 K124 H162 Y165 P166
Binding residue
(residue number reindexed from 1)		D8 A9 V10 G11 R12 D100 K116 H154 Y157 P158
Enzymatic activity
Enzyme Commision number 3.1.26.4: ribonuclease H.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0004519 endonuclease activity
GO:0004523 RNA-DNA hybrid ribonuclease activity
GO:0030145 manganese ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006298 mismatch repair
GO:0006401 RNA catabolic process
GO:0043137 DNA replication, removal of RNA primer
GO:1990516 ribonucleotide excision repair
Cellular Component
GO:0005737 cytoplasm
GO:0032299 ribonuclease H2 complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7uwh, PDBe:7uwh, PDBj:7uwh
PDBsum7uwh
PubMed37196657
UniProtP10442|RNH2_ECOLI Ribonuclease HII (Gene Name=rnhB)

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