Structure of PDB 7rj1 Chain C Binding Site BS02

Receptor Information

>7rj1 Chain C (length=263) Species: 237561 (Candida albicans SC5314)

SMDFMKPETVLDLANIRQALVRMEDTIVFDLIERSQFFSSPSVYEKNKYN
IPNFDGTFLEWALLQLEVAHSQIRRYEAPDETPFFPDQLKTPILPPINYP
KILAKYSDEINVNSEIMKFYVDEIVPQVSCGQGDQKENLGSASTCDIECL
QAISRRIHFGKFVAEAKYQSDKPLYIKLILDKDVKGIENSITNSAVEQKI
LERLIVKAESYGVDPSLNVQSKVKPEVIAKLYKDWIIPLTKKVEIDYLLR
RLEDEDVELVEKY

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 7rj1 Chain C Residue 302

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7rj1 Crystal structure of Aro7p chorismate mutase from Candida albicans, complex with L-Trp
• Resolution: 2.16 Å
• Binding residue (original residue number in PDB): D29 E147
• Binding residue (residue number reindexed from 1): D30 E148
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 5.4.99.5: chorismate mutase.

Gene Ontology

Molecular Function

• GO:0004106 chorismate mutase activity
• GO:0016853 isomerase activity
• GO:0046872 metal ion binding
• GO:0072545 L-tyrosine binding
• GO:0120284 tryptophan binding

Biological Process

• GO:0006571 tyrosine biosynthetic process
• GO:0009073 aromatic amino acid family biosynthetic process
• GO:0009094 L-phenylalanine biosynthetic process
• GO:0046417 chorismate metabolic process

Cellular Component

• GO:0005575 cellular_component
• GO:0005634 nucleus
• GO:0005737 cytoplasm

External links

• PDB: RCSB:7rj1, PDBe:7rj1, PDBj:7rj1
• PDBsum: 7rj1
• UniProt: Q59TS4